Electrooxidative Synthesis of Bis- and Oligoarenes

在这个联合项目中，将探索和定义取代芳烃的新型电氧化联芳偶联的机理和范围。这种电化学方法的优点是联芳基交叉偶联不需要留下官能团。由于这种无试剂和无金属的电有机工艺不产生任何试剂废物，因此将建立一种高度可持续的合成方法。利用电和溶剂效应来指导交叉偶联的选择性，在当代有机合成中创造了一种前沿技术。这种基于亲核性和氧化电位解耦的创新交叉耦合概念可以被认为是一种新型的偶联材料，是出色的偶联选择性的来源。这种新方法的效率将被用于基于芳基和季芳基结构的a-螺旋模拟物的高效和模块化合成。该战略涉及现代金属催化步骤和电合成转换的互补组合，不需要留下功能，并提供直接和可持续的访问这些实体。

In this joint project, the mechanism and scope of a new electrooxidative biaryl coupling of substituted arenes will be explored and defined. This electrochemical approach has the advantage that no leaving functionalities are required for biaryl cross-coupling. Since no reagent waste is formed in this reagent- and metal-free electroorganic process, a highly sustainable synthetic method will be established. The use of electricity and solvent effects to direct the selectivity of the cross-coupling creates a cutting-edge technique in contemporary organic synthesis. This innovative cross-coupling concept based on the decoupling of nucleophilicity and oxidation potential the substrates can be considered as a new type of umpolung and is the source of the outstanding coupling selectivity. The efficiency of this new methodology will be exploited for the efficient and modular synthesis of mimetics for a-helices based on teraryl and quateraryl architectures. The strategy involves a complementary combination of modern metal-catalyzed steps as well as electrosynthetic transformations which do not require leaving functionalities and provide a direct and sustainable access to such entities.