Magnetic particle imaging: Development and evaluation of novel methodology for the assessment of the aorta in vivo in a small animal model of aortic aneurysms

与其他成像方式相比，例如磁共振成像（MRI）， MPI允许磁性颗粒的3D成像，具有更高的灵敏度和时间分辨率。使用MPI的初步结果显示了这种新技术在进行血管造影方面的潜力。拟议的项目将建立在DFG主要设备行动的基础上，该行动已资助柏林的临床前MPI扫描仪。该项目的目的是：1)为MPI开发新的图像采集和重建技术，以改善血管造影的采集和血管壁氧化铁颗粒摄取的量化。2)在动物主动脉瘤模型上测试这些新的获取技术。特别是MPI的空间和时间分辨率将得到验证。此外，我们将评估MPI是否能在早期和延迟扫描（例如给药24小时后）准确量化动脉壁中积累的氧化铁颗粒。我们将比较MPI和MRI的表现来表征主动脉瘤，并通过MR松弛测量和易感性制图来量化氧化铁摄取。所有体内结果将使用包括组织学和质谱在内的参考方法进行体外验证。

Compared to other imaging modalities, e.g. magnetic resonance imaging (MRI), MPI allows for 3D imaging of magnetic particles with a significantly higher sensitivity and temporal resolution. Preliminary results using MPI have shown the potential of this novel technology to perform angiographies. The proposed project will build on the DFG major equipment action that has funded a preclinical MPI scanner in Berlin. The aim of this project is: 1) to develop novel image acquisition and reconstruction techniques for MPI to improve the acquisition of angiographies and the quantification of iron oxide particle uptake in vessel wall. 2) to test these novel acquisitions techniques in an animal model of aortic aneurysm. In particular the spatial and temporal resolution of MPI will be validated. Additionally, we will evaluate whether MPI can accurately quantify iron oxide particles that accumulate in the arterial wall, on early and delayed scans (e.g. 24 hours after administration of particles). We will compare the performance of MPI with MRI to characterize aortic aneurysms and quantify iron oxide uptake by MR relaxometry and susceptibility mapping. All in vivo results will be validated ex vivo using reference methods including histology and mass spectroscopy.