ヒト疾患バイオマーカーの生体外単一分子検出の為の流体光学プラズモンプラットホーム

我在《欧洲物理学快报》上发表了一篇观点论文。本文综述了无金属表面增强拉曼光谱的理论，包括电磁增强和化学增强，并介绍了最近发展起来的有前景的衬底材料，包括MXenes、过渡金属二卤化物和碳基衬底。此外，我们还阐明了挑战，提供了潜在的解决方案，并讨论了未开发的应用。这一视角不仅提供了现阶段无金属SERS的广泛和详细的观点，而且还为其未来的发展提供了路线图。我向先进光学材料提交了一篇论文，目前正在进行审查。在这篇文章中，我们展示了一种高度可扩展、可穿戴的SERS传感器，该传感器基于一种易于制造、低成本、超薄、灵活、可拉伸、粘合和可生物集成的金纳米网格。它可以制造成任何形状，几乎可以佩戴在任何表面上，用于从低浓度到高浓度的各种分析物的无标签、大规模、原位检测。为了展示可穿戴SERS传感器的实用价值，我们测试了该传感器对汗液生物标记物、滥用药物和微塑料的检测。这种可穿戴的SERS传感器代表着朝着可穿戴传感技术的通用性和实用性迈出的重要一步。我在欧洲研究日上展示了我的早期成果-欧洲在日本的研究人员：作为受邀演讲者的成就和机会，以及在JSPS科学对话倡议下在东京都科学技术高中传播科学的一些更通用的概念。

I published an perspectives paper in Europhysics Letters. We review the theory of metal-free SERS, including electromagnetic enhancement and chemical enhancement, and introduce promising substrates developed recently, including MXenes, transition metal dichalcogenides, and carbon-based substrates. Moreover, we clarify challenges, provide potential solutions, and discuss unexploited applications. This perspective provides not only a broad and detailed view of metal-free SERS at the current stage, but also a roadmap for its future advancement.I submitted a paper to Advanced Optical Materials that is currently under review. In this paper we demonstrate a highly scalable, wearable SERS sensor based on an easy-to-fabricate, low-cost, ultrathin, flexible, stretchable, adhesive, and bio-integratable gold nanomesh. It can be fabricated in any shape and worn on virtually any surface for label-free, large-scale, in-situ sensing of diverse analytes from low to high concentrations. To show the practical utility of the wearable SERS sensor, we test the sensor for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step toward the generalizability and practicality of wearable sensing technology.I presented my early results at the EUROPEAN RESEARCH DAYS - European Researchers in Japan: Achievements and Opportunities as an invited speaker and some more generic concepts at the Tokyo Metropolitan High School of Science and Technology under the JSPS Science Dialogue initiative to disseminate science.