Molecular imaging and modulation of fibrosis and inflammation incardiac pressure overload and relief

在项目10中，基于磁共振成像（MRI）和正电子发射断层扫描（PET）的定量成像分析将结合起来，用于无创检测心脏生物变化，以响应心脏压力过载和缓解。此外，与其他器官和系统的串扰将通过全身成像进行研究。多模式方法将有助于深入表征炎症和纤维化的各个方面，以及它们随时间的变化。成像也将用于指导靶向分子治疗，并确定治疗的成功（“图像引导治疗”）。在实验动物中产生的假设将在来自衰竭心脏的人体组织样本中进行交叉验证，这将为成功的临床转化提供基础。由于多模态成像在动物模型和临床环境中的广泛可行性，以及对多器官的适用性，该项目将与临床研究小组的许多项目紧密联系，以促进他们的成功。

In project 10, quantitative imaging assays based on magneticresonance imaging (MRI) and positron emission tomography (PET)will be combined for noninvasive detection of biological changes inthe heart in response to cardiac pressure overload and relief. Inaddition, crosstalk with other organs and systems will be investigatedby whole-body imaging. The multimodal approach will facilitate an indepth characterization of various aspects of inflammation and fibrosis,along with their changes over time. Imaging will also be used to guidetargeted molecular therapies and to determine the success oftreatment (“image-guided therapy”). The hypotheses generated inexperimental animals will be cross-validated in human tissue samples from failing hearts, which will serve to provide the basis for successfulclinical translation. Owing to the broad feasibility of multimodalimaging in animal models and clinical settings, along with applicabilityto multiple organs, this project will tightly network with many projectsof the clinical research group in order to facilitate their success.