Ameliorating Cognitive Control in Binge Eating Disorder by Electrical Brain Stimulation (ACCElect)

BED患者形成了一个肥胖患者亚组，其饮食模式与认知控制的重大障碍相关。dlPFC已被确定为与认知控制过程密切相关的大脑区域，并在控制进食行为中起关键作用。这表明，dlPFC作为一个目标的调制认知控制过程中吃在床上。这种调节可以通过认知训练任务和使用tDCS的非侵入性脑刺激来实现。在对健康正常体重参与者的研究中，（1）不同的认知训练任务增强了对饮食行为的控制，（2）tDCS是改善认知控制过程的有效工具，（3）对饮食行为的动机方面（即食物渴望）具有有益的影响。基于这一证据，我们将使用认知控制任务和tDCS的组合来增强BED患者对进食的认知控制。据我们所知，这是第一项在BED患者中使用非侵入性脑刺激的研究，也是第一项使用tDCS作为干预措施以增强对进食的认知控制的研究之一。

Patients with BED form a subgroup of obese patients with a disinhibited eating pattern that is associated with major impairments in cognitive control. The dlPFC has been identified as a brain region closely tied to cognitive control processes and crucially involved in the control of eating behaviour. This suggests the dlPFC as a target for the modulation of cognitive control processes over eating in BED. This modulation can be achieved by both, a cognitive training task and by non-invasive brain stimulation using tDCS. In studies with healthy normal-weight participants, (1) different cognitive training task enhance control over eating behaviour, (2) tDCS is an effective tool to ameliorate cognitive control processes, and (3) has beneficial effects on motivational aspects of eating behaviour, i.e. food craving. Based on this evidence, we will use a combination of a cognitive control task and tDCS to enhance cognitive control over eating in patients with BED. This is to the best of our knowledge the first study to use non-invasive brain stimulation in BED patients and one of the first studies to use tDCS as an intervention to enhance cognitive control over eating.