High Resolution EM Tomography of Specialised Plasma Membrane Domains

该项目将在两个主要领域为国家带来好处。首先，这些研究将大大增加我们对细胞结构的理解，这对身体细胞的功能至关重要。从三维角度理解动物细胞组成部分的结构，将为了解细胞在健康状态下的工作方式以及疾病中出现的问题提供长期的好处。其次，这个项目将使我们能够发展电子显微镜断层扫描的新方法，并将其应用于生物学中的一个关键问题。这将是未来几年澳大利亚调查人员的一项重要技术，该项目将使科学家和学生接受这些最先进技术的培训。

This project will provide National benefits in two major areas. Firstly, these studies will greatly increase our understanding of the cellular structures which are crucial to the functioning of cells in the body. Understanding the structure of the components of animal cells in three dimensions will provide long-term benefits in the quest to understand how a cell works in health and what goes wrong in disease. Secondly, this project will allow us to develop the new method of electron microscope tomography and apply it to a crucial question in biology. This will be a vital technique for Australian investigators in the coming years and this project will allow scientists and students to be trained in these state-of-the-art techniques.