IN VIVO CHARACTERIZATION OF RNA VIRUS ASSEMBLY LINES WITH EM TOMOGRAPHY

利用电子断层扫描技术对 RNA 病毒组装系进行体内表征

• 批准号: 8361915
• 负责人: John Emil Johnson
• 金额: $ 2.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361915
• 关键词: Direct Costs; Electron Microscope; Facilities and Administrative Costs; Funding; Future; Grant; Human; Image Analysis; Influenza; National Center for Research Resources; Principal Investigator; RNA Viruses; Research; Research Infrastructure; Research Personnel; Resources; Societies; Source; United States; United States National Institutes of Health; Vaccines; Viral; Virus; Virus Assembly; cost; human disease; in vivo; novel; pandemic disease; pathogen; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Viruses are the cause of many human diseases through out the world, and result in major financial losses to society. In the United States Influenza, a human pathogen, is responsible for an estimated total direct and indirect cost of $10 billion per year, and the costs of a serious future pandemic could cost hundreds of billions of dollars. Investigating virus assembly and entry will help researchers develop novel anti-viral targets and vaccines. The focus of this proposal is to use to electron microscope tomography to answer key questions about RNA virus lifecycle in vivo.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 病毒是世界各地许多人类疾病的原因，并导致社会造成重大财务损失。在美国，人类病原体，估计的直接和间接成本为每年100亿美元，而严重的未来大流行的成本可能需要数亿美元。研究病毒组装和进入将有助于研究人员开发新的抗病毒靶标和疫苗。该建议的重点是用于电子显微镜断层扫描，以回答有关体内RNA病毒生命周期的关键问题。