The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking

这项拟议的研究代表着突破性的科学，将导致在分子水平上对逆转录复合体的结构和组装以及它如何调节内体系统中受体的分类有一个基本的了解。它将在构成最先进的结构和分子细胞生物学研究的多学科方法方面为顶尖研究生和博士后科学家提供出色的研究培训。通过解决一个国际上非常感兴趣的领域，该项目将有能力增加澳大利亚的知识基础，并加强其卓越研究的声誉。

The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the-art structural and molecular cell biology research. By addressing an area of great interest internationally the project will have the capacity to increase Australia's knowledge base and strengthen it's reputation for research excellence.