Development of atom-economical and stereoselective catalytic radical reactions

催化是科学的一个使能的分支，提供新材料和新工艺。因此，它非常适合为现代社会的需求提供可持续的解决方案。正如Anastas[1]所指出的那样，这是因为催化可以用于选择性工艺的设计，最大限度地增加产品中的原材料量，使用可再生能源和避免产生废物。我们已经证明，自由基是有吸引力的关键中间体，可持续的催化，通过开发系统的自由基还原或芳基化，通过耦合的催化循环和环氧化物氢化硅烷化。这些结果为新型高立体选择性和可持续自由基反应的高效催化剂的机制指导设计开辟了道路。

Catalysis is an enabling branch of science providing access to novel materials and processes. It is therefore ideally suited to deliver sustainable solutions for the demands of modern societies. As pointed out by Anastas[1] this is so, because catalysis can be employed in the design of selective processes that maximize the amount of raw material ending up in the product, in the use of renewable energy sources and in avoiding the production of waste. We have demonstrated that radicals are attractive as key-intermediates for sustainable catalysis by developing systems for radical reduction or arylation through the coupling of catalytic cycles and for epoxide hydrosilylations. These results lead the way for a mechanism-guided design of efficient catalysts for new and highly stereoselective as well as sustainable radical reactions.