Impact of host genetic variation and environmental influences on the cutaneous microbiome composition

皮肤微生物组的组成可能有助于广泛的健康和疾病状态，包括慢性炎症性皮肤病。它是由环境和宿主（遗传）成分共同塑造的。与人类微生物组计划在不同身体部位对健康皮肤微生物群进行分类的大规模努力相比，在表征影响皮肤微生物组的宿主和环境因素方面所做的工作相对较少。迄今为止，还没有全基因组研究试图描述人类基因组中可能形成皮肤微生物组组成的特定基因和途径，并且对特定的外在个体依赖因素（如紫外线照射，宠物暴露和饮食习惯）的影响知之甚少。最后，到目前为止，皮肤和身体其他部位的微生物组组成之间的潜在相关性尚未得到研究。因此，拟议的项目旨在全面分析人类遗传变异和选定的环境因素对基因组和微生物组范围内3个地点皮肤微生物生态系统组成的影响，并在包括386名（KORA）和600名（POPGEN）成年人在内的两个具有良好特征的人群为基础的队列中检查皮肤和肠道微生物组的一致性。

The composition of the skin microbiome likely contributes to a wide-range of health and disease states including chronic inflammatory skin diseases. It is shaped by both environmental and host (genetic) components. In contrast to the large-scale efforts of the Human Microbiome Project to catalogue the healthy cutaneous microbial flora at different body sites, relatively little has been accomplished to characterize the host and environmental factors impacting the skin microbiome. To date, there are no genome-wide studies that have attempted to characterize specific genes and pathways in the human genome that may shape the composition of the skin microbiome, and relatively little is known on the impact of specific extrinsic individual-dependent factors such as UV-exposure, pet exposure and dietary habits. Finally, potential correlations between the microbiome composition at the skin and other body sites have not been examined so far. The proposed project therefore aims at comprehensively profiling the impact of human genetic variation and selected environmental factors on the composition of the cutananeous microbial ecosystem at 3 sites on a genome- and microbiome-wide scale, and to examine the concordance of skin and gut microbiomes, in two well characterized population-based cohorts comprising 386 (KORA) and 600 (POPGEN) adults.