Biopsychological stress regulation in burnout

职业倦怠（BO）是工作紧张和慢性工作压力的潜在后果。虽然BO不是一种正式的临床诊断，但它被DGPPN（“Deutsche Gesellschaft für Psychiatrie，Psychotherapie und Nervenheilkunde”）承认为一个存在的重要问题。BO综合征主要是一种主观的疾病模型，因此，对（工作）超负荷或脆弱性的各种影响是开放的。因此，BO可以归因于异质人群。这可以解释为什么到目前为止，生物心理学研究未能显示关于BO现象的生物心理学相关性的一致结果。该项目追求的问题是，与健康对照组相比，出现BO症状的受试者是否显示出改变的心理内分泌和神经应激调节以及非稳态负荷，这取决于症状的严重程度。我们根据BO症状和发病机制选择参与者，并通过自我和其他评级进行验证，因此该程序是当前项目的独特功能。为此，在两个日期（T1和T3）以6个月的间隔从参与者收集非稳态负荷参数（包括毛发和血液样品）。此外，我们首次调查了在功能磁共振成像环境（T2）中急性应激暴露下BO症状患者的神经激活。目前的项目持续时间为36个月，外加3个月的电晕紧急支持。随着项目KU 1401/9-1的更新建议，我们申请为一名博士生延长6个月的工作人员拨款。由于2019冠状病毒病大流行，实验室被关闭，因此，在过去14个月（持续）根本无法收集数据或仅在非常有限的程度上收集数据。迄今为止，已招募128名受试者，76名受试者已完全完成研究。在T1和117名参与者接受了fMRI检查（T2），从104人中收集了非稳态负荷参数。初步结果表明，BO症状的人可能显示出止血平衡的转变。此外，我们能够成功地建立和发布应力协议的修改以及ScanSTRESS数据的新分析策略（Henze等人，2020年），并在本项目中应用。在正常情况下，数据收集将按原计划完成至2021年3月。然而，由于新型冠状病毒疫情，数据收集工作将延迟至二零二一年底╱二零二二年初完成。由于最终（生化）数据分析和手稿准备只能在完成数据收集后进行，我们希望为一名博士生申请6个月的工作人员资助，以（部分）补偿因Covid-19而关闭的实验室。

Burnout (BO) is a potential consequence of job-related strain and chronic work stress. Although BO is not an official clinical diagnosis, it is acknowledged as an existing and significant problem by the DGPPN (“Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde”). The BO-syndrome is predominantly a subjective model of disease and is, thus, open for various effects of (work) overload or vulnerability. Therefore, BO can be ascribed to heterogeneous groups of people. This could explain why until now biopsychological studies failed to show consistent results regarding biopsychological correlates of the BO-phenomenon. The projec pursues the question whether subjects who developed BO symptoms, compared to healthy controls, show altered psychoendocrine and neural stress regulation as well as allostatic load, depending on symptom severity. We select participants based on BO symptoms as well as pathogenesis, verified by self- and other ratings, whereby this procedure is a unique feature of the current project. For this purpose, allostatic load parameters (including hair and blood samples) are collected from participants at intervals of 6 months on two dates (T1 & T3). In addition, we investigate for the first time the neural activation in persons with BO symptoms under acute stress exposure in an fMRI environment (T2).The current project duration is 36 months plus 3 months of corona emergency support. With this renewal proposal of project KU 1401/9-1, we apply for a 6 months extension of the staff appropriations for one PhD student. Owing to the Covid-19 pandemic, laboratories were closed and therefore, data collection was not possible at all or only to a very limited extent in the last 14 months (and enduring). To date, 128 subjects have been recruited and 76 subjects have already fully completed the study. Allostatic load parameters were collected from 104 persons at T1 and 117 participants underwent the fMRI examination (T2). Preliminary results indicate that persons with BO symptoms possibly show a shift in hemostatic balance. Moreover, we were able to successfully establish and publish modifications of the stress protocol as well as a new analytic strategy for ScanSTRESS data (Henze et al., 2020), which are applied in the current project. Under normal conditions, data collection would have been completed until march 2021 as planned in the original schedule. However, due to Covid-19 the completion of data collection will delay until end of 2021/beginning of 2022. As final (biochemical) data analysis and manuscript preparation can only take place after completion of data collection, we would like to request for a 6 months extension of staff funding for one PhD student to (partially) compensate for the laboratory closedown due to Covid-19.