Coordination

微生物和非感染性损伤会引发截然不同的炎症反应模式，这取决于刺激物和受影响组织。选择正确的免疫反应质量决定了它是否有效和有益，或者相反，造成额外的损害。2型免疫是指由蠕虫感染、过敏原和毒液激活的反应模式，但也在受伤组织的修复过程中激活。它是由细胞因子IL-4、IL-5和IL- 13的显性环境定义的。术语“2型反应”既包括组织的“先天”2型反应，也包括随后的适应性TH2和IgE反应，后者由初始先天反应指导。虽然2型免疫在防御、组织修复和代谢调节中起关键作用，并且是过敏性和纤维化疾病的驱动因素，但控制2型免疫反应的因素仍不清楚。我们的目标是阐明在正常组织中诱导和调节2型免疫的基本机制，以及在需要2型免疫保护或作为疾病促进剂的病理中。FOR2599整合了促进2型反应的重要细胞类型生物学方面的领先专家，包括M2巨噬细胞、先天淋巴样细胞、树突状细胞、嗜酸性粒细胞和嗜碱性粒细胞以及肥大细胞。该小组结合了调节2型反应的关键信号通路的专业知识，并拥有独特的创新遗传小鼠品系和体内疾病模型。这可以实现巨大的协同作用，使FOR2599处于理想的位置，以阐明在稳态或不同性质和强度的组织应激条件下，各种组织细胞如何相互作用以建立和调节局部2型反应。

Microbial and non-infectious insults trigger distinct inflammatory response patterns that fundamentally differ, dependent on the stimulus and the affected tissue. The choice of the right quality of immune response determines whether it will be efficient and beneficial or, on the contrary, cause additional damage. Type 2 immunity designates the response pattern activated by helminth infection, allergens and venoms, but also during the repair process in wounded tissue. It is defined by a dominant milieu of the cytokines IL-4, IL-5 and IL- 13. The term “type 2 response” embraces both the ‘innate’ type 2 responses of tissues and the subsequent adaptive TH2 and IgE responses, the latter being instructed by the initial innate response. While type 2 immunity serves key functions in defense, tissue repair and metabolic regulation, and is the driver of allergic and fibrotic disease, factors controlling type 2 responses are still unclear. We aim to elucidate the fundamental mechanisms that induce and regulate type 2 immunity in normal tissues, and in pathologies where type 2 immunity is required for protection, or is a promoter of disease. FOR2599 integrates leading experts in the biology of important cell types that contribute to type 2 responses, including M2 macrophages, innate lymphoid cells, dendritic cells, eosinophilic and basophilic granulocytes and mast cells. The group combines expertise in key signaling pathways regulating type 2 responses and has available a unique spectrum of innovative genetic mouse lines and in vivo disease models. This enables tremendous synergy, putting FOR2599 in an ideal position to elucidate how the various tissue cells interact to mount and regulate a local type 2 response in steady state or under conditions of tissue stress of different nature and intensity.