Organocatalytic Deprotonation Reaction Using Onium Amide

从选择性、安全性和可持续性的角度来看，有机催化过程被认为是有吸引力的，并且用于芳香族化合物和杂芳香族化合物的去质子官能化的有机催化过程的开发被认为是有机合成中极具挑战性的课题之一。我们一直致力于芳香族和杂芳香族化合物的有机催化转化，我们开发了一种简单的催化脱质子功能化的杂芳环在无金属的温和条件下使用铵酰胺，生成的氨基硅烷和鎓氟化物的组合原位，作为碱。

Organocatalytic process has been regarded to be attractive from viewpoints of selectivity, safety, and sustainability, and the development of organocatalytic processes for deprotonative functionalization of aromatics and heteroaromatics is considered to be one of highly challenging subjects in organic synthesis. We have been working on organocatalytic transformation of aromatic and heteroaromatic compounds, and we developed a simple catalytic deprotonative functionalization of heteroaromatic ring under metal-free mild conditions using onium amides, generated in situ from the combination of aminosilanes and onium fluorides, as bases.