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Liver regeneration using stem cells from hteeth (SHED) for congenital metabol

Liver regeneration using stem cells from hteeth (SHED) for congenital metabol
使用来自牙齿的干细胞(SHED)进行先天性代谢的肝脏再生
批准号:
23659618
负责人:
TAGUCHI Tomoaki
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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中文摘要
翻译
结果表明,Share既具有MSC的特性,又具有HSC的特性。去除低表达的人类白细胞抗原。在培养液中,SHEAD被成功诱导为肝细胞样细胞。在CCl4诱导的肝硬变和肝豆状核变性中,这些肝细胞样细胞附着在受损的肝组织上。这些细胞可以组成球状结构。另一方面,使用3D生物打印机建立了肝脏的三维结构。
英文摘要
SHED was shown to have the character of MSC as well as HSC. SHED low expression of HLA. SHED was successfully induced to the hepatocyte-like cell in medium. These hepatocyte-like cells were settled to the damaged liver tissue in CCl4 induced liver chirrhosis as well as Wilson disease. These cells could compose the sphere structure. On the other hand, 3D liver structure was built using 3D bioprinter.
期刊论文(29)
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会议论文
Potent induction of IFN-γ production from cord blood NK cells by the stimulation with single-strand RNA.
通过单链 RNA 刺激,有效诱导脐带血 NK 细胞产生 IFN-γ。
DOI: --
发表时间: 2011
期刊: J Clin Immunol
影响因子: 9.1
作者: [Eljaafari FM, Takada H, Tanaka T, Doi T, Ohga S, Hara T]
通讯作者: Hara T
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Alatas FS, Yamaza T, Yamaza H, Hayashida M, Yanagi Y, KukitaT, Nonaka K, Ohga S, Taguchi T, Hayashida M, Matsuura T, Saeki I, Yanagi Y, Taguchi T]
通讯作者: Hayashida M, Matsuura T, Saeki I, Yanagi Y, Taguchi T
DOI: 10.1097/pas.0b013e318205df36
发表时间: 2011-02-01
期刊: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
影响因子: 5.6
作者: [Fujita, Kohei, Yamamoto, Hidetaka, Oda, Yoshinao]
通讯作者: Oda, Yoshinao
Correlation between the Number of segmental chromosome aberrations and the age at diagnosis of diploid neuroblastomas without MYCN amplification.
无 MYCN 扩增的二倍体神经母细胞瘤节段染色体畸变数量与诊断年龄之间的相关性。
DOI: --
发表时间: 2011
期刊: Journal of Pediatric Surgery
影响因子: 2.4
作者: [Sozaki R, Tajiri T, Teshiba R, Kinoshita Y, Yosue R, Kohashi K, Oda Y, Taguchi T]
通讯作者: Taguchi T
共 26 条
    Elucidation of the etiology and development of the novel therapy using stem cells from human exfoliated deciduous teeth for Hirschsprung's disease and its allied disorders
    • 批准号:
      16H02682
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $30.37万
    • 财政年份:
      2016
    • 负责人:
      TAGUCHI Tomoaki
    • 依托单位:
    Development of new therapies for intractable diseases in pediatric surgery using stem cells from human exfoliated deciduous teeth
    • 批准号:
      25253094
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $27.12万
    • 财政年份:
      2013
    • 负责人:
      TAGUCHI Tomoaki
    • 依托单位:
    New therapeutic method of Hirschsprung's disease and its variants by using the stem cells from human exfoliated deciduous teeth
    • 批准号:
      25670744
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      TAGUCHI Tomoaki
    • 依托单位:
    New treatment using gene induction and regenerative medicinefor diaphragmatic agenesis
    • 批准号:
      21390475
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.07万
    • 财政年份:
      2009
    • 负责人:
      TAGUCHI Tomoaki
    • 依托单位:
    海外基金