Role of ADP ribosyl cyclase in pathogenesis of preeclampsia

妊娠20周后发生的先兆子痫（PE）、高血压和蛋白尿是导致母亲和胎儿死亡的原因。 目前拯救母亲和/或婴儿的唯一确定性治疗方法是引产。 妊娠期间可接受的降压药有助于控制PE中的母体血压，但不能预防早产，也不能纠正与PE相关的胎儿生长受限。 我们已经证明，烟酰胺降低具有先兆子痫样病症的小鼠的高血压和蛋白尿，延迟流产并消除胎儿生长受限。 烟酰胺是第一种通过靶向PE中特异性功能失调的途径而使母亲和后代受益的物质。 它值得评价用于预防或治疗人类PE。

Pre-eclampsia (PE), hypertension and proteinuria developing after 20 weeks of gestation, is the cause of maternal and fetal deaths. The only definitive treatment currently available to save the mother and/or the baby is induced delivery. Anti-hypertensives acceptable for use during pregnancy help control maternal blood pressure in PE, but they do not prevent pre-term delivery nor correct the fetal growth restriction associated with PE. We have demonstrated that nicotinamide reduces the hypertension and proteinuria in mice having a pre-eclampsia-like condition, delays miscarriages and alleviates the fetal growth restriction. Nicotinamide is the first substance that benefits both mother and offspring by targeting a pathway specifically dysfunctional in PE. It merits evaluation for preventing or treating PE in humans.