Development of a novel human leukemia model using humanized mice

将原发性人白血病细胞移植到免疫缺陷小鼠体内的体内研究，为我们了解人白血病的发病机制提供了重大进展。然而，在这些模型中，白血病细胞在移植到小鼠体内之前已经在人类患者体内发育，因此不适合研究生理性白血病的发生。因此，我们在这里开发了一种新的实验模型来分析白血病发生，在这种模型中，人类原代造血干细胞通过故意的基因撞击转化为白血病细胞。我们希望这一新建立的人源化小鼠模型将有助于未来的研究，旨在揭示白血病发生的分子机制和开发新的治疗白血病的方法。

In vivo studies in which primary human leukemia cells were transplanted into immunodeficient mice, provided significant advances in our understanding of the pathogenesis of human leukemia. However, these models, in which the leukemia cells had already developed in human patients before being transplanted into mice, are not suitable for studying physiological leukemogenesis. Therefore, we here developed a new experimental model for analyzing leukemogenesis in which primary human HSCs are converted into leukemia cells by deliberate genetic hits. We hope that this newly established model using humanized mice will contribute to future studies aimed at revealing the molecular mechanisms for leukemogenesis and developing new therapies against leukemia.