T-cell costimulation-mediated regulation of mucosal inflammation

我们在OX40配体转基因(OX40L-TG)小鼠中检测了可能使C57BL/6(B6)小鼠易感IBD和BALB/c小鼠对IBD产生抗性的一个数量性状基因座(QTL)。该基因座对IBD严重程度的ODD(LOD)评分显示极显著的对数。利用该基因座的单核苷酸多态(SNPs)进一步定位，发现了TNFRSF14基因的SNP的最低p值(&lt；10-7)。TNFRSF14编码疱疹病毒进入介体(Hvem)，属于肿瘤坏死因子受体r超家族。

We examined a quantitative trait locus (QTL)that may make C57BL/6 (B6)mice susceptible and BALB/c mice resistant to IBD developing in OX40 ligand-transgenic (OX40L-Tg)mice. The locus exhibits highly significant logarithm of odd (LOD)score for the IBD severi ty. Further positional mapping performed using single nucleotide polymorphisms (SNPs)at this locus revealed the lowest p-value (<10-7 )for the SNP in TNFRSF14 gene. TNFRSF14 encodes the herpes virus entry mediator (HVEM), which belongs to the TNF recepto r superfamily.