T-cell costimulation-mediated regulation of mucosal inflammation

我们检查了一个数量性状基因座 (QTL)，该基因座可能使 C57BL/6 (B6) 小鼠对 OX40 配体转基因 (OX40L-Tg) 小鼠中的 IBD 易感，而 BALB/c 小鼠对 IBD 具有抗性。该基因座对 IBD 严重程度表现出高度显着的奇数对数 (LOD) 分数。使用该位点处的单核苷酸多态性 (SNP) 进行的进一步定位作图揭示了 TNFRSF14 基因中 SNP 的最低 p 值 (<10-7)。 TNFRSF14 编码疱疹病毒进入介质 (HVEM)，属于 TNF 受体超家族。

We examined a quantitative trait locus (QTL)that may make C57BL/6 (B6)mice susceptible and BALB/c mice resistant to IBD developing in OX40 ligand-transgenic (OX40L-Tg)mice. The locus exhibits highly significant logarithm of odd (LOD)score for the IBD severi ty. Further positional mapping performed using single nucleotide polymorphisms (SNPs)at this locus revealed the lowest p-value (<10-7 )for the SNP in TNFRSF14 gene. TNFRSF14 encodes the herpes virus entry mediator (HVEM), which belongs to the TNF recepto r superfamily.