T-cell costimulation-mediated regulation of mucosal inflammation

T 细胞共刺激介导的粘膜炎症调节

• 批准号: 21390114
• 负责人: ISHII Naoto
• 金额: $ 11.9万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390114/
• 关键词: 炎症性腸疾患; 疾患感受性遺伝子; 遺伝子導入マウス

We examined a quantitative trait locus (QTL)that may make C57BL/6 (B6)mice susceptible and BALB/c mice resistant to IBD developing in OX40 ligand-transgenic (OX40L-Tg)mice. The locus exhibits highly significant logarithm of odd (LOD)score for the IBD severi ty. Further positional mapping performed using single nucleotide polymorphisms (SNPs)at this locus revealed the lowest p-value (<10-7 )for the SNP in TNFRSF14 gene. TNFRSF14 encodes the herpes virus entry mediator (HVEM), which belongs to the TNF recepto r superfamily.

我们在OX40配体转基因(OX40L-TG)小鼠中检测了可能使C57BL/6(B6)小鼠易感IBD和BALB/c小鼠对IBD产生抗性的一个数量性状基因座(QTL)。该基因座对IBD严重程度的ODD(LOD)评分显示极显著的对数。利用该基因座的单核苷酸多态(SNPs)进一步定位，发现了TNFRSF14基因的SNP的最低p值(&lt；10-7)。TNFRSF14编码疱疹病毒进入介体(Hvem)，属于肿瘤坏死因子受体r超家族。

项目成果

Positional identification of TNFRSF14, encoding the herpes virus entry mediator, as a susceptibility gene for inflammatory bowel disease in mice

编码疱疹病毒进入介质的 TNFRSF14 作为小鼠炎症性肠病易感基因的位置鉴定

• 发表时间: 2010
• 作者: Kawabe T;Irie M;Ono M;Asao A;Zhang M;Yoshida A;Takahashi T;Uede T;Watanabe N;Sugamura K;and Ishii N.
• 通讯作者: and Ishii N.

In vivo assay of human NK-dependent ADCC using NOD/SCID/γcnull (NOG) mice

• DOI: 10.1016/j.bbrc.2010.07.145
• 发表时间: 2010-09-03
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Shiokawa, Miho;Takahashi, Takeshi;Ishii, Naoto
• 通讯作者: Ishii, Naoto

Characterization of the EpCAM+ cell population in hepatocellular carcinoma cell lines

肝细胞癌细胞系中 EpCAM 细胞群的表征

• 发表时间: 2010
• 期刊: Cancer Sci
• 影响因子: 5.7
• 作者: Kimura;O.;Takahashi;T.;Ishii N;Inoue;Y.;Ueno;Y.;Kogure;T.;Fukushima;K.;Shiina;M.;Yamagiwa;Y.;Kondo;Y.;Inoue;J.;Kakazu;E.;Iwasaki;T.;Kawagishi;N.;Shimosegawa;T.;and Sugamura;K
• 通讯作者: K

Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1

• DOI: 10.1093/cvr/cvn244
• 发表时间: 2009-01-01
• 期刊: CARDIOVASCULAR RESEARCH
• 影响因子: 10.8
• 作者: Satoh, Kimio;Fukumoto, Yoshihiro;Shimokawa, Hiroaki
• 通讯作者: Shimokawa, Hiroaki

OX40-Mediated Susceptibility to Leishmania major Infection is Dependent on IL-13

OX40 介导的利什曼原虫重度感染的易感性取决于 IL-13

• 发表时间: 2010
• 作者: Asao A;Ndhlovu LC;Hoshino T;Sugamura K;and Ishii N.
• 通讯作者: and Ishii N.