Designing protein-incorporating scaffolds for periodontal tissue engineering

近年来，利用间充质干细胞和生物可降解支架进行牙周组织再生的研究受到广泛关注。目前最重要的挑战之一是加速新骨组织的形成。在这项研究中，我们筛选了各种生长因子及其组合，以确定最佳的因素纳入支架增强骨形成。因此，我们发现BMP-2掺入到支架材料中对于制备骨组织支架是最有效的。进行进一步的研究以鉴定对生物可降解聚合物支架具有亲和力的肽。结果发现，具有特定序列的肽显示出对聚乳酸的亲和性。根据这一结果，我们提出，当与生长因子融合时，这种肽将有效地用于构建生长因子/支架复合物。

Recently much attention has been paid to periodontal tissue regeneration using mesenchymal stem cells and biodegradable scaffolds. One of the most important challenges at this moment is to accelerate the formation of new bone tissues. In this study, we screened various growth factors and their combinations to identify the best factors to be incorporated into scaffolds for the enhanced bone formation. As a result, we found that incorporation of BMP-2 into scaffold materials is most effective for the preparing bone tissue scaffolds. Further study was carried out to identify peptides that have an affinity for biodegradable polymer scaffolds. As a result, it was found that the peptide having a specific sequence exhibited an affinity for poly(lactic acid). According to this result, we propose that, when fused with a growth factor, this peptide would be effective for constructing growth factor/scaffold composites.