Development of novel preventive strategy for post-infarct cardiac rupture via the regulation of inflammatory process by the activation of natural killer T cells

心肌梗死（MI）可导致心脏破裂和心力衰竭的发展，两者都是心肌梗死后患者死亡的主要原因。慢性组织炎症在心肌梗死后左室重构和心脏破裂的病理过程中起重要作用。不变性自然杀伤T （iNKT）细胞通过调节各种细胞因子的产生来协调组织炎症。α -半乳糖神经酰胺（α - gc）特异性激活iNKT细胞，可能有助于保护心脏免受急性缺血性损伤。

Myocardial infarction (MI) leads to the development of cardiac rupture as well as heart failure, both of which are the major causes of death in post-MI patients. Chronic tissue inflammation plays an important role in the pathological process of post-MI left ventricular remodeling as well as cardiac rupture. Invariant natural killer T (iNKT) cells orchestrate tissue inflammation via regulating the production of various cytokines. The activation of iNKT cells by alpha-galactosylceramide (alpha-GC), which specifically activates iNKT cells, could be beneficial to protect the heart from acute ischemic injury.