Biofabrication of heart substitute tissue based on bioink from spider silk proteins (C01)

心脏病是一个主要的社会经济负担。尽管在预防和减少心脏损伤方面取得了相当大的进展，但心功能不全的患病率仍在不断增加。该子项目的目的是使用3D打印技术可重复生产分层组织的人类心脏替代组织。为此，将使用hipsc衍生的心脏细胞、在第一个资助期开发的蜘蛛丝蛋白、排列纤维和可灌注的管状结构。长期目标是治疗心脏病。

Heart diseases are a major socioeconomic burden. Despite considerable progress in the prevention and minimization of heart damage, the prevalence of heart insufficiency increases continuously. The aim of this subproject is the reproducible production of hierarchically organized human cardiac substitute tissue using 3D printing technology. For this purpose, hiPSC-derived cardiac cells, spider silk proteins developed during the first funding period, aligned fibers, and perfusable tubular structures will be used. The long-term goal is the treatment of heart diseases.