Molecular regulation of epigenetics of the cytochrome P450 genes by food chemicals

已知P450是一种有用的生物催化剂，可以进行药物和化学品的单氧化。特别是P450可以对参与癌细胞生成的各种化学物质进行代谢激活。我们知道含有致突变性的化学物质会增加我们体内的癌细胞。一般来说，这些诱变化学物质是由P450单加氧酶代谢激活的。另一方面，关于非诱变化学物质的激活机制的信息很少。在本研究中，我们发现异硫氰酸盐是一种非食品来源的致突变性物质，可以调节P450 mRNA的总量。

It is known that P450 which is a useful biological catalyst can carry out the monooxigenation of the medicine and chemicals.Especially P450 can carry out metabolic activation of various chemical substances which participate in the generation of cancer cells. We know that the chemical substance with has mutagenicity can increase the cancer cells in our body. In general, these mutagenic chemicals are metabolic activated by P450 monooxygenase. On the other hand, there is a little information about the mechanism for the activation of non-mutagenic chemicals. In this research, we show that the isothiocyanate which is a non-mutagenicity substance of food origin can regulate the total amount of mRNA of P450.