The Basic and Clinical Studies of Interstitial Hyperthermia of Brain Tumors using

我们发现Fe-Pt合金（Fe: 73%i Pt: 27%，居里点：68）是种植体加热系统（IHS）的最佳种植针。我们开发了his用于临床研究。IHS由三部分组成：植入针、感应线圈和发电机。种植针直径1.8mm，长度分别为15、20、25 mm，居里点设置为68。感应线圈直径为30cm，线圈中心的最大磁场强度为16.7 Oe。还有发电机。具有最大功率的2.5倍，产生240 khz的高频。实验研究我们研究了在中等温度下HeLa细胞中hsp-70的细胞内易位。当细胞在高于41℃的温度下加热时，热休克蛋白70在10分钟内从细胞质转移到细胞核中，并明显积聚在核仁中。在42℃以上的温度下，热休克蛋白70在加热过程中仍留在原子核中。然后，我们研究了hhs单次高温治疗兔舌瘤模型（VX-7癌）后组织酚含量的变化。距植入针5mm处肿瘤组织呈凝固性坏死。坏死灶形状不规则，并逐渐向舌周延伸，持续3天。安全、反复、长期治疗不能手术的复发性脑肿瘤(胶质瘤：13例，Meta。： 7例，其他：5例)已由IHS制作。在诱导热疗之前，根据肿瘤的大小，通过CT引导立体定向将一个或多个植入物放置在肿瘤内或在开颅时手动插入。所有病例均接受反复热疗，并联合放疗或化疗。临床反应为CR 3例，PR 5例，MR 4例，ST 3例，PD 8例。应用IHS治疗口腔癌13例（舌7例，口底2例，牙龈2例，上颚1例，唇部1例）。3例采用IHS +放疗+化疗，3例采用IHS +化疗（CDDP: 200mg, PEP: 70-80mg）。其余7例均行his、化疗及手术治疗。临床缓解9例，PR 4例

l. Development of Implant Heating System (IHS)We observed that the Fe-Pt afloy (Fe : 73%i Pt : 27%, -Curie point : 68) is the best implant needle of the Implant Heating System (IHS). And we developed IHS for clinical study. The IHS consists of three parts : implant needle, induction coil and generator. The implant needle is 1.8mm in diameter and 15, 20, 25 mm in length, of which Curie pointa is set at 68. The induction coil is 30 cm in diameter, maximum magnetic field strength at the center of the coil is 16.7 Oe. And the generator. has 2.5 kill of maximum power, yielding the high frequency of 240 kHz.2. Experimental studiesWe have investigated intracellular translocation of hsp-70 during at moderate temperatures in HeLa cells. When cells were heated at temperatures above 41, hsp-70 translocated from the cytoplasm into the nuclei and apparently accumulated in nucleoli within, 10 min. At temperatures above 42, hsp-70 remained in the nuclei during, heating.Then we studied the histopathol … More ogical changes in rabbit tongue tumor model (VX-7 carcinoma) after single treatment of hyperthermia using IHS. The tumor tissue at 5mm apart from implant needle was showed coagulation necrosis. The necrotic lesion -was irregular shaped and tended to extend gradually toward the peripheral side of the tongue for 3 days.3. Clinical studiesSafe, repeated and longterm treatment of 25 cases of inoperable, recurrent brain tumors (Glioma : 13cases, Meta. : 7cases, Others : 5cases) have been made by the IHS. Before inducing hyperthermia, one or more implants were placed within the tumor by CT guided stereotaxis or inserted manually at craniotomy depending on the size of tumors. All the cases received repeated hyperthermia, combined with either radiotherapy or chemotherapy. The clinical response were 3 CR, 5 PR, 4 MR, 3 ST and 8 PD.Thirteen cases (tonque : 7cases, mouth floor : 2cases, gingiva : 2cases, palate : lcase lip : lcase) of oral cancer has been treated by IHS. Three cases were treated by IHS, irradiation and chemotherapy, and three cases were treated by IHS and chemotherapy (CDDP : 200mg, PEP : 70-80mg). The other 7 cases were treated by IHS, chemotherapy and operation. The clinical response were 9 CR and 4 PR. Less