MECHANISM OF MAINTENANCE OF POTASSIUM HOMEOSTASIS IN NERVOUS SYSTEM BY GLIAL-NEURONAL INTERACTION

研究发现，K^+的体内平衡至少通过三个过程来维持。从电生理和电镜研究中分别揭示了快速和中等加工是由于横向扩散和横向扩散通过微管系统穿过许旺细胞。用全细胞膜片钳技术对酶法分离的雪旺细胞进行研究，发现这一缓慢过程与雪旺细胞的离子机制有关。我们发现了至少三种电压敏感电流：内向Ca^2+敏感外向K^+电流和在超极化电压下出现的内向整流电流。

The K^+ homeostasis was found to be maintained at least three processes. The fast and medium processed were revealed to be due to lateral diffusion and transversal diffusion through microtubular system across the Schwann cell, respectively from the electrophysiological and electron microscopic studies. The slow process was found to be related to ionic mechanism of the Schwann cell by whole cell-patch clamp studies on enzymatically isolated Schwann cells. We found at least three voltage sensitive currents ; inward Ca^<2+> -sensitive outward K^+ current, and inwardly rectifying current that appeared at hyperpolarizing voltages.