Functional proteomics dissection of phagocyte derived signals during CNS inflammation and recovery (A07)

吞噬细胞、胶质细胞和神经元之间的交流调节中枢神经系统的内稳态。由于对细胞间信号深入研究的技术限制，目前尚不清楚吞噬细胞来源的信号如何诱导破坏性组织炎症的形成，而来自同一细胞的信号如何促进炎症的消退和随后的组织修复。我们的目标是开发先进的基于质谱的蛋白质组学工具来解剖吞噬细胞和中枢神经系统驻留细胞之间的信号交换，以确定毒性和炎症性损伤小鼠模型中神经恢复的共享分子检查点。

Communication between phagocytes, glia and neurons regulates homeostasis in the CNS. Due to technical limitations in studying intercellular signals thoroughly, it is still unclear how phagocyte derived signals can induce the formation of destructive tissue inflammation, while signals from the same cells promote the resolution of inflammation and subsequent tissue repair. We aim to develop advanced mass spectrometry-based proteomics tools to dissect signals exchanged between phagocytes and CNS resident cells, to identify shared molecular checkpoints of neuro-recovery across mouse models of toxic and inflammatory injury.