Additive manufacturing of bone replacement implants from crystallising bioactive glasses

生物活性玻璃的增材制造（AM）用于骨置换植入物，具有可调节的结晶性，可以实现复杂的形状，定制的孔隙度和腔结构，释放治疗离子，控制材料降解，以及对细胞形成和生长的良好刺激。尽管有许多有前途的优点，但生物活性玻璃结晶的增材制造几乎没有研究过。特别是，这种知识的缺乏包括增材制造工艺参数对烧结、结晶和玻璃粉末压坯形状稳定性的影响。此外，关于结晶度、孔隙度和孔隙空间结构对生物活性的影响的基本知识是缺失的。因此，本项目重点研究生物活性玻璃复合支架的增材制造及其生物活性。由于生物活性玻璃通常表现出强烈的结晶倾向，因此研究其对AM和生物活性（包括细胞形成、生长和材料降解）的影响是所提出的工作包的关键部分。

Additive manufacturing (AM) of implants for bone replacement from bioactive glasses with tuneable crystallisation enables complex shapes, tailored porosity and cavity architecture, the release of therapeutic ions, controlled materials degradation, and a good stimulus of cell formation and growth. Despite its numerous promising advantages, additive manufacturing from crystallising bioactive glasses has hardly been studied. In particular, this lack of knowledge comprises the effects of AM processing parameters on sintering, crystallisation, and shape stability of glass powder compacts during manufacture. Furthermore, fundamental knowledge about the influence of crystallinity, porosity and pore space architecture on bioactivity is missing. This project therefore focusses on the AM of complex scaffolds from bioactive glasses and their bioactivity. As bioactive glasses commonly exhibit strong crystallisation tendency, the study of its effect on AM and bioactivity including cell formation, growth and materials degradation is the key part of the proposed working packages.