Studies on the combination therapy of radiofrequency capacitive heating and interstitial heating for malignant brain tumor.

为了确保无线电需求（RF）电容加热对恶性脑肿瘤的影响，一个新的内部加热系统已经开发和开发了一个重要性，并评估了使用射频电容和内部加热的组合疗法的可能性。对于内部加热，我们选择微波中的射频。由于微波无法穿透10毫米以外的深区的原因，而且微波应用器的最小直径是3毫米，太大，无法插入大脑。我们设计了不同类型的针型射频应用程序。多针应用程序是由柔性电线制成的，它有可能加热大脑的可选和良好的本地区域。对于射频电容加热系统的进一步评估我们已经开发了，我们已经进行了这个系统的临床应用。15名患有胶质瘤的患者被用外链加热方法安全地治疗。However，大脑深处的地区没有足够的加热和残留在40 - 42 ° C.在我们新开发的中间加热系统中没有技术性的应用，这个新系统可以覆盖射频电容加热系统的弱点。

To faciliate the effects of radiofrequency (RF) capacitive heating on malignant brain tumor, a new interstitial heating system was developed and the significance and the possibility of the combination therapy of hyperthermia using RF capacitive and interstitial heating was evaluated.For interstitial heating, we chose RF instead of microwave, for the reason that microwave could not penetrate into the deep region beyond 10 mm in our phantom study and that the minimal diameter of the microwave applicator was 3 mm and too big to be inserted into the brain. We designed various types of needle type RF applicators. The multible needle applicators made of flexible wire made it possible to heat accurately and safely the optional and well-localized areas of the brain.For further evaluation of the RF capacitive heating system which we had already developed, we proceeded to the clinical application of this system. Fifteen patients with glioblastoma were treated by extracranial heating method safely. However, the deep region of the brain was heated insufficiently and remained 40 - 42゜C.There is no technical problem in the clinical application of our newly developed interstitial heating system and this new system could cover the weak points of the RF capacitive heating system.