A role of membrane-associated proteins in synaptic Plasticity.

在这个项目中，我们试图了解膜相关的Ca^<2+>/钙调蛋白结合蛋白、钙调蛋白和4.1样蛋白的表达是否与大鼠视觉皮层突触可塑性程度的发育变化有关。免疫组化染色表明，这些蛋白在出生后10-34天的视觉皮质神经元中的表达最为明显，此后到成年后变得非常弱。由于已知视觉皮层的突触可塑性在10-34天处于最高水平，而成熟皮层的突触可塑性非常低，因此目前的研究结果表明，这些膜相关蛋白可能在发育中的视觉皮层的突触可塑性中发挥作用。

In this project we attempted to see whether or not an expression of membrene-associated, Ca^<2+>/calmobulin-binding proteins, calspectin and 4.1-like protein, is related to developmental changes in the degree of synaptic plasticity in the rat visual cortex. Immunohistochemical stainings of these proteins demonstrated that their expressions in visual cortical neurons were most marked during 10-34 postnatal days and became very weak thereafter to the adult. Since synaptic plasticity in the visual cortex is known to be at the highest level during 10-34 days and very low in the matured cortex, the present results suggest that these membrane-associated proteins may play a role in synaptic plasticity in the developing visual cortex.