Simulation and Clinical Implication of Peripheral Circulation

外周循环的模拟和临床意义近年来，在日本，由于动脉狭窄或血栓形成而导致的动脉功能不全更常见并得到治疗。对动脉循环的客观分析和理解在治疗这些患者中似乎是至关重要的。在这项研究中，开发了一个计算机程序来模拟动脉循环，并设计了非创伤性超声仪器来测量下肢几个位置的血压和流量。这些收集的临床信息和计算机模拟输出用于客观的临床评估。仿真模型和程序的开发：选择下肢动脉系统作为原型。本文建立了下肢循环的电学和数学模型，并采用三元件电路模拟法编制了PC-9801计算机模拟程序，其中V为血压，R为特征动脉阻抗，C为血管床电容。测量节段性血压和血流参数值并记录到数据记录仪中。这些测得的压力和流量波形用于计算输入阻抗谱。临床意义：下肢动脉循环的数据化和精确评估，首先通过无创超声仪收集临床信息，然后通过计算机模拟程序将这些信息进行处理，将有助于预测和评估治疗结果和患者的自然病程。血管阻力增加和疾病引起的顺应性下降的影响通过计算机图形得到了很好的理解。通过改变模拟程序中的参数值，也可以显示某种药物或手术的想象或预期结果。

Simulation and Clinical Implication of Peripheral CirculationArterial insufficiency due to stenosis or thrombosis is more often seen and treated in japan in recent years. An objective analysis and understanding of the arterial circulation seems to be a paramount importance in treating these patients. In this study, a computer program to simulate the arterial circulation was developed and non-traumatic ultrasonic apparatus to measure blood pressure and flow at several locations of the lower extremity were devised. These collected clinical informations and their computer simulation outputs were utilized for objective clinical assesment.Development of Simulation Model and Program: The arterial system of the lower extremity was chosen as a prototype. An electrical and mathematical model of the lower extremity circulation was constructed and a simulation program for the personal computer(PC9801) was developed by a three element circuit analog, where V is blood pressure, R is characteristic arterial impedance and C are capacitance of the vascular bed. Segmental blood pressure and flow parameter values were measured and recorded to data recorder. These measured pressure and flow wave forms were used to calculate the input impedance spectrum. The program was again evaluated by comparing clinical measurements and the flow pressure wave forms generated by computer.Clinical Implication: Datail and precise asseessment of the arterial circulation of the lower extremity, first by collecting the clinical informations using non-traumatic ultrasonic apparatus and then by subjecting the informations to the computer simulation program, would help predict and evaluate treatment results and patient's natural course. Effects of increased vascular resistance and ailed compliance due to diseases are well understood by computer graphics. Imaginary or expected results of a certain medication or operation are also shown by changing parameter-values in the simulation programs.