Analysis of thermoregulatory and pyretic responses in heat-and cold-acclimation

本研究旨在从人类和动物中枢神经系统的下丘脑和下丘脑外热敏的概念出发，阐明热适应的中枢和外周机制。鼠兔的热原性和较差的热损失反应：鼠兔较好的热保存能力被认为是由于其较高的代谢率。散热能力差，散热能力弱，耳表面积小。此外，据报道鼠兔对麻醉品明显敏感，但对LPS热原的腹腔注射反应不佳。然而，在本研究中，鼠兔显然可以通过内源性LPS热原引起发热，但热损失机制与白化兔不同，即鼠兔的蒸发热损失能力差，很可能是由于耳朵作为散热器很小，缺乏热呼吸。热适应引起的脑血流量（CBF）的变化；脑血流的变化与空气温度密切相关…更多的温度和温度调节参数。与对照组相比，热驯化兔的CBF因加热而增加的幅度较小，因冷却而减少的幅度较小，冷驯化兔的CBF因加热而减少的幅度也较小。热适应和冷适应兔在一般的加热和冷却以及热原给药过程中，热调节反应增益的减少，因此热适应过程中脑脑血流变化的减少可能导致热冷刺激下热反应的习惯化现象。热干桑拿热运动交叉适应分析热适应过程能够诱导运动员和热带受试者的热适应，这可能与其固有的体质特征和获得的耐热性密切相关，而运动员的结果可能是由于热负荷和运动负荷合作产生的更大的交叉适应性而增强的产热能力和蒸发热损失反应能力。为了明确甲状腺激素对热出汗的影响，本研究采用电容式湿度计-吸汗胶囊法测定甲状腺功能亢进和甲状腺功能减退患者的热出汗情况。然而，各种激素对热出汗的影响以及激素对出汗的作用部位和机制还需要进一步的研究。少

This investigation was designed to clarify the central and peripheral mechanism of thermal acclimation from the concept of hypothalamic and extra-hypothalamic thermosensitivity of CNS in human and animal.I. Pyrogenic and poor heat loss responses in pika (Whistle rabbit): Pika,s better heat conservation ability thought to be due to its higher metabolic rate. poor heat dissipation through the weak thermal panting and smaller ear surface area. Further, it was reported that pika is markedly senitive to narcotics, but it responds poorly to i.p. administration of LPS pyrogen. However, in the present study, it was clear that pika can elicit fever with i.v. LPS pyrogen but heat loss mechanism differs from that of albino rabbit, that is, the poor evaporative heat loss ability in pika is most probable due to smallness of the ear as a heat radiator and lack of thermal panting.II. Changes in cerabral blood flow (CBF) due to theraml acclimation; the change in CBF is closely associated with air temp … More erature as well as thermoregulatory parameters. Not only the less increase in CBF due to heating but also less decrease due to cooling was observed in the heat-acclimated rabbit compared to those of control rabbit, and similar results were obtained in the cold acclimated rabbit. The reduction of gain in thermoregulatory responses occurred during general heating and cooling as well as pyrogen administration in both heat- and cold- acclimated rabbits, so the reduced change in CBF of brain in the process of the thermal acclimation might cause habituation phenomenon of thermal responses to heat and cold stimulation.III. Analysis of heat-exercise cross adaptation in hot dry sauna; the heat acclimation procedure is capable of inducing heat acclimation to the sportsmen as well as the tropical subjects who may be closely related to inherent consititutional characteristic and his acquired heat tolerance, and the results of the spotsmen may be due to the enhanced ability of heat production and evaporative heat loss response owing to larger cross adaptability by co-operation of heat and exercise load.In this investigation, to clarity the effect of thyroid hormone on thermal sweating, thermal sweating in patients with hyperthyroidism and hypothyroidism was determined by using of capacitance hygrometer-sweat capture capsule method. However, further reseaches are necessary to clarity the effects of various hormones on thermal sweating and the action site of hormones on sweating mechanism. Less