Objective visual functions in macular diseases

本文应用眼底监测系统对人的黄斑部局灶性视网膜电图进行了研究，探讨了其适宜的记录条件和功能特性。通过提高信噪比，我们成功地记录到了人黄斑区的振荡电位（OPs），以及a波、b波和关闭反应。研究了OPs与a波和b波中OPs的关系。黄斑上部的a波、b波和OPs的振幅均明显大于黄斑下部，黄斑部的OPs振幅随光斑大小和环形刺激的变化表明，OPs在黄斑中心凹内的分布相对稀疏，从黄斑中心凹向黄斑旁，OPs的分布相对较a波和b波密集，向黄斑中心凹周围，OPs的分布更为明显。颞、鼻黄斑区a、b波振幅差异无统计学意义。然而，在tempor中， ...更多信息 黄斑区明显大于鼻黄斑区。我们研究了几种具有局灶性黄斑ERG的黄斑疾病，包括a波、b波、关闭反应和OPs。在某些黄斑疾病中，如糖尿病性黄斑病变，c）（干性黄斑水肿或特发性中心性浆液性脉络膜视网膜病变的恢复期，黄斑OP选择性减少，留下a波和b波完整。黄斑区OPs是评价黄斑功能的敏感指标，我们研制了一种由改进的眼底照相机、独立的视路和计算机组成的中心凹锥体密度测量仪，采用双向密度技术，可以客观地测量中心凹锥体色素的密度和再生时间。黄斑中心凹视锥密度测定法可以阐明黄斑病变中一些不能用心理物理学或电生理学技术确定的方面，通过结合这两种方法，可以通过客观测量的视觉功能对黄斑病变进行逐层分析。少

The studies of focal macular ERG have been made with special reference to its suitable recording condition and functional properties by using fundus monitoring system in human. By improving the signal to noise ratio, we successfully recorded the oscillatory potentials (OPs) in addition to a-wave, b-wave and, offresponse in human macular region. The distribution of OPs in relation to those in a-wave and b-wave was studied. The amplitude of a-wave, b-wave and OPs of the upper macular region was significantly larger than that of lower macular region.The changes of amplitude in response to the spot size and ring stimuli indicated that the distribution of OPs is relatively sparse in the fovea, and it becomes relatively more dense than those of a-wave and b-wave from the fovea toward the parafovea, and even more strikingly toward the perifovea. There was no statistical difference of amplitude in both a-wave and b-wave between temporal and nasal macula. However, the amplitude of OPs in tempor … More al macula was significantly larger than that in nasal macula. we studied several macular diseases with focal macular ERG in terms of a-wave, b-wave, off-responses and OPs. In some macular diseases, such as diabetic maculopathy, c)(stoid macular edema or convalescent stage of idiopathic central serous chorioretinopathy, the macular OPs were selectively reduced, leaving the a-wave and b-wave intact. The macular OPs can be a sensitive indicator to assess the macular function in several macular diseases.We built a prototype apparatus for foveal cone densitometry that combined a modified fundus camera, independent optic pathways, and a personal computer.Using a two-way density technique, the density and regeneration time of the foveal cone pigment can be measured objectively: Foveal cone densitometry may elucidate some aspects of macular pathology that cannot be ascertained by psychophysical or electrophysiological techniques.By combining these two methods, layer-by-layer analysis of macular diseases can be performed by objectively measured visual functions. Less