Reserch on Spinal Reconstruction for Malignant Spinal Tumors and Development of Biomaterials and Spinal Instrumentation

屈曲状态下整个腰椎的计算模拟利用单元模型对屈曲状态下的整个腰椎进行了计算模拟。结果表明，在恒定弯曲力作用下，腰椎5个间盘的应力分布基本相同。另一方面，在剪切力作用下，下部病变椎间的应力越大。2.脊柱固定装置的生物力学评价6种脊柱固定装置所提供的三维稳定性在体外生物力学模型中进行了研究。在T12-L1处，完全横断后半部和后半部，造成损伤。对于所有载荷类型的胸腰椎后路损伤模型，外固定架是唯一能提供足够稳定性的装置。带有横向固定器的KANEDA器械是第二个最稳定的…器械A-WGC椎体间隔器与前路器械置换术的实验研究我们用含磷灰石和硅灰石的微晶玻璃(A-W)制备了一种人工椎体间隔器，用于犬腰椎置换术。GC)。5只狗接受了A-WGC椎体间隔器的整个椎体置换。术后6~14个月处死动物，对A-WGC与骨的界面进行放射学和组织学检查。未发生A-WGC接骨。应用A-WGC椎体间隔器和Kaneda器械对6例转移性脊柱肿瘤患者进行脊柱前路重建。疼痛缓解率100%，神经功能恢复率100%。患有严重疼痛和脊髓和/或神经根受压的患者从这次手术中受益。较少

Computational simulation of the whole lumbar spine under flexionComputational simulation of the whole lumbar spine under flexion were carried out using the element model. As a result, in flexion at constant moment ,the stress distributions of five intervertebral discs in the lumbar spine are almost the same. On the other hand, at shear force, the stress of discs in the lower lesion are higher.2 Biomechanical evaluation of spinal fixation deviceThe three-dimentional stability provided by six spinal fixation devices has been studied in an in vitro biomechanical model using five-vertebral (Tll-L3) fresh cadaveric thoracolumbar specimens. An injury was created at T12-L1 by complete transection of the posterior elements and posterior half of of the intervertebral disc. External skeletal fixation was the only device that provided sufficient stability for thoracolumbar posterior injury model for all load types. The Kaneda device with transverse fixators was the next most stable instrumentatio … More n.3 Experimental study of vertebral replacement with A-WGC vertebral spacer and anterior instrumentationWe prepared a artificial vertebral spacer for the replacement of the lumbar vertebral of dog, using apatite-and wollastonite-containing glass-ceramic (A-W. GC). Five dogs underwent replacement of a whole vertebral body with A-WGC vertebral spacer. The animals were killed at intervals from six months to 14 months after operation, and the interface between A-WGC and bone was examined radiolpgically and histologically. Bone bonding with A-WGC had not occurred. More rigid fixation of the A-WGC vertebral spacer is required for bonding to bone.4 Anterior spinal reconstruction for the metastatic patients, using A-WGC vertebral spacer and Kaneda deviceSix patients suffering from matastatic spinal tumor were treated with A-WGC vertebral spacer and Kaneda device. The rates of positive recovery were as follows : 100% for pain relief, and 100% for neurologic recovery. Patients suffering from severe pain and spinal cord and/or nerve root compression benefited from this surgery. Less