Pharmacological studies on central nervous control systems in gastric acid secretion and on their signal tranduction systems.

从药理学角度探讨胃酸分泌的中枢神经控制系统及其信号转导系统与食欲控制和胃溃疡治疗的关系。在脑肠相互作用方面，研究了食欲控制物质降钙素的作用。降钙素通过中枢机制对胃分泌有明显的抑制作用。中枢5 -羟色胺能机制与降钙素的作用密切相互作用，类似于吗啡对胃酸分泌的抑制作用。在本研究过程中，偶有发现戊巴比妥对尿素麻醉大鼠胃酸分泌有较强的刺激作用。在戊巴比妥的作用机制中，中枢GABA机制起着重要作用。在我们之前的研究中，我们发现TRH和GABA可以刺激胃酸分泌，作为脑功能不足的改善剂。在这方面，研究了几种用于脑供血不足的药物对胃酸分泌的影响。hoptenate Ca^<2+>， γ -氨基- β -羟基丁酸酯和citicholine对胃酸分泌有明显的刺激作用。从目前的结果来看，可能在某些方面，脑代谢状态反映在胃酸分泌上。关于GABA，我们研究了一些谷氨酸激动剂对胃分泌的影响。kainic acid的刺激作用显著，谷氨酸和NMDA的刺激作用较弱，而quisqualate的刺激作用不明显。这些相当新颖的发现将刺激这一领域的进一步研究。我们发现几种三环类抗抑郁药相关化合物对胃酸分泌有较强的抑制作用。除上述结果外，我们还成功地为脑-肠失衡疾病建立了新的胃溃疡模型。总的来说，我们的研究项目计划顺利完成。少

Central nervous control systems and their signal transduction systems in gastric acid secretion were investigated in relation to appetite control and gastric ulcer therapy on the basis of pharmacology.In relation to brain-gut interaction, the effect of an appetite control substance, calcitonin was studied. A remarkable depressive effect of calcitonin on gastric secretion via central mechanisms was found. Close interaction with central serotonergic mechanisms with the action of calcitonin was confirmed similar to the inhibitory effect of morphine on gastric acid secretion.In the course of the present study, we occasionally found that a general anesthetic, pentobarbital has a strong stimulatory effect on gastric acid secretion in the urethan anesthetized rats. In the mechanism of action of pentobarbital, the important contribution of central GABA mechanism was found.In our previous study, TRH and GABA were found to stimulate gastric acid secretion which are used as the brain insufficienc … More y improver. In this connection, the effects of several drugs used for cerebral insufficiency were investigated on gastric acid secretion. Hopantenate Ca^<2+>, gamma-amino-beta-hydroxy butyrate and citicholine were found to possess distinctive stimulatory effects on gastric acid secretion. From the present results, a possibility was suggested that, in some aspect, brain metabolic state may reflect on gastric acid secretion.In relation to GABA, we investigated the effect of some glutamate agonists on gastric secretion. A remarkable stimulatory effect of kainic acid was found as well as weak effects of glutamic acid and NMDA, but not of quisqualate. These quite novel findings will stimulate further investigation in this field. We found the strong inhibitory effect of several tricyclic antidepressant related compounds on gastric acid secretion. In addition to the above mentioned results, we succeeded to device new gastric ulcer models for the brain-gut imbalance diseases.In total, our research project plan was successfully achieved. Less