Electrophysiological studies on the action of antipsychotic drugs

1.海马点燃的研究(1)记录在2hz点燃刺激下穿孔通路触发的齿状回场诱发电位的动态变化。我们的研究结果表明，在癫痫后放电出现后，成对脉冲抑制的崩溃，应该表现为刺激部位周围的局部抑制性截击。(2) GABA-B拮抗剂和NMDA拮抗剂对癫痫发作阈值的升高比对AD的降低更优先。K^+开启剂和AMPA拮抗剂的抗癫痫作用谱相反。自发活性多巴胺细胞的研究(1)氟西汀，一种血清素摄取抑制剂，增加了多巴胺细胞的数量。PCPA会减少大脑中血清素的含量。(2)神经激肽拮抗剂和神经激肽拮抗剂均能减少多巴胺细胞的数量。(3)与Fisher大鼠相比，Lewis大鼠多巴胺细胞数量少，多巴胺细胞破裂模式多，多巴胺受体易感性增强。

1.Research on hippocampal kindling(1) We recorded the dynamic changes of field evoked potentials of dentate gyrus triggered by perforant pathway during the 2Hz-kindling stimulation. Our result showed that the collapse of paired-pulse depression, which should show the local inhibitory volley around the stimulating site, occurred after the appearance of epileptic afterdischarge.(2) GABA-B antagonist and NMDA antagonists caused the elevation of seizure threshold more preferentially than the reduction of AD.K^+opener and AMPA antagonist showed the opposite spectrum of antiepileptic action.2.Research on spontaneously active dopamine cells(1) Fluoxetine, a serotonin-uptake inhibitor, increased the number of dopamine cells. PCPA,which depletes the content of serotonin of the brain, decreased it.(2) Neurotesin antagonist and Neurokinin antagonist both decreased the number of dopamine cells.(3) Lewis rats showed less number of dopamine cells, more bursting pattern of dopamine cells and more increased susceptibility of dopamine reseptors, compared with Fisher rats.