A CASE-CONTROL STUDY OF OVARIAN CANCER.SURVEY IN JAPAN FOR COMPARISON AMONG JAPANESE IN JAPAN,JAPANESE IN U.S.A., AND WHITE IN U.S.A.

目的：分析日本女性潜在危险因素与卵巢癌的关系。方法：我们于1994年10月至1996年1月在九州北部进行了一项病例对照研究。我们采访了78例经组织学确诊的卵巢癌患者，以及346名在大规模筛查中被确定为未患癌症或卵巢疾病的对照组。结果：母亲或姐妹患卵巢癌家族史(OR=2.85，95%CI 1.01~8.08)、既往最大体重较重(趋势OR=1.35，95%CI 1.06~1.63)、最大体重指数较大(趋势OR=1.30，95%CI 1.06~1.60)显著增加。相反，妊娠次数(趋势，OR=0.67，95%CI 0.51-0.89)、产次(趋势，OR=0.57，95%CI 0.39-0.83)、口服避孕药经验(P&lt；不孕症或月经紊乱的激素治疗与卵巢癌风险无关。讨论：最大体重或体重指数与卵巢癌风险呈正相关，这可能部分解释了最近日本卵巢癌发病率上升的原因。

Purpose : To analyze the association between the potential risk factors and ovarian cancer among Japanese women.Method : We conducted a case-control study from October, 1994 to January, 1996, in northern Kyushu. We interviewed 78 cases whose ovarian cancer was histologically confirmed, and 346 controls who were identified at mass screening and who were evaluated as not having a cancer or an ovarian disorder. An odds ratio (OR) and its 95% confidence interval (95%CI) was estimated with the conditional logistic regression.Results : The risk was significantly increased for family history of ovarian cancer in a mother or a sister (OR=2.85,95%CI 1.01-8.08), for heavier maximum body weight in the past (trend, OR=1.35,95%CI 1.06-1.63), and for larger maximum body mass index (trend, OR=1.30,95%CI 1.06-1.60). Conversely, the risk was significantly decreased with the number of pregnancy (trend, OR=0.67,95%CI 0.51-0.89), with the number of parity (trend, OR=0.57,95%CI 0.39-0.83), and with experience in having ever taken oral contraceptive pills (p<0.05, OR could not be calculated because of null frequency in the cases).Treatment with hormonal drugs for infertility or menstrual disorder was not associated with the ovarian cancer risk.Discussion : The positive relationship of maximum body weight or body mass index to the ovarian cancer risk may in part explain the recent increase of the incidence of ovarian cancer in Japan.