The ApoE Interactome in Human Plasma

在这个后基因组时代，重点已经从描绘基因组结构转向描述基因产品的巨大任务。在这个新时代发展的一个重要方面是设计能够识别全球蛋白质-蛋白质相互作用的策略，人类蛋白质组组织将其定义为相互作用组。这是人类血浆中的apoE相互作用组项目，将确定血浆蛋白和apoE之间的新相互作用，apoE是一种脂质结合蛋白，在基因上与影响50多万澳大利亚人的年龄相关疾病有关。因此，该项目将为新的治疗方法和疾病的早期发现提供空间，即心血管和阿尔茨海默病。

In this, the post-genome era, the emphasis has switched from the delineation of genome structure to the tremendous task of characterizing the gene products. One of the important aspects evolving in this new era is the design of strategies that enable identification of global protein-protein interactions, defined by the Human Proteome Organisation as the interactome. This, the apoE interactome in human plasma project, will identify novel interactions between plasma proteins and apoE, which is a lipid-binding protein genetically linked to age-related diseases affecting more than 500,000 Australians. This project will therefore provide scope for novel treatments and early detection of disease, namely cardiovascular and Alzheimer's disease.