ER stress and presbycusis

我们试图通过给两种不同类型的小鼠服用内质网应激阻滞剂TUDCA来治疗老年性耳聋。其中一种类型的小鼠的老年性耳聋是由听觉毛细胞的进行性丧失引起的，而TUDCA不能减轻这种情况。另一方面，在另一种类型的小鼠中，长期持续服用TUDCA在统计学上显著地预防了部分由螺旋神经节细胞丢失所促进的衰老。这一结果暗示了未来通过减少内质网应激来减轻老年性耳聋的可能性。

We tried to treat presbycusis by giving a ER stress-blocker, TUDCA, to different two types of mice. Presbycusis in one type of mice is promoted by progressive loss of auditory hair cells, which was not able to be attenuated by administratin of TUDCA. On the other hand, presbysis in the other type of mice which is promoted partly by loss of spiral ganglion cells was statistically significantly prevented by long-term continueous administration of TUDCA. The results were suggestive of future possibility of attenuating presbycusis by reducing ER stress.