Molecule gene analysis of bone absorption in bone reproduction medical care and development of bone absorption restraint medicine

肌肉注射（1 mg/kg）免疫抑制剂FK 506至裸鼠和T细胞连续28天遭受损失的野生型小鼠，并制作骨质疏松模型小鼠，以通过免疫抑制剂寻找细胞促免疫性和与骨质疏松症发病的相关性。结果，对于FK 506实验组的骨吸收，野生型比软骨内骨化更能识别骨小梁的减少，而对于阳性破骨细胞，TRAP染色的软骨内骨化的数量增加再次比对照组更明显。然而，对于下部的骨吸收，对于免疫抑制剂引起的骨质疏松症，由于没有控制和变化，除了用裸鼠进行的软骨内骨化外，还暗示了免疫系统细胞如T细胞的相关性。 ...更多信息 n产品（PC），这是一个瑞士奶酪的启动器，以这种骨质疏松症模型。我们这次检查了该发酵产物的骨吸收抑制效果。当我通过FK 506给骨质疏松症小鼠施用丙酸菌发酵产物（PC）时，我能够阻止骨吸收。近年来，许多现有的DHNA具有与维生素K2相同的萘醌框架，在PC内具有一定量的骨改善作用的骨盐物质中引起注意。我注意到这一点，当我们单独给予DHNA时，我们接受了与骨质疏松模型PC相同的骨吸收抑制。至于DHNA，PC的骨吸收抑制作用能够通过DHNA从PC中大量包含的物质中识别出。当我在小鼠的破骨细胞中加入作为T细胞的B细胞和作为骨髓中四扭CD阳性的B220阳性，即体外的骨芽细胞时，我将破骨细胞与对照进行了比较。如磁珠作用下的打击罗马细胞和骨髓细胞明显增加。少

Intramuscular injection (1 mg/kg) did immunity restraint agent FK506 to a nude mouse and a mouse of a wild type that a T cell suffered a loss day after day on 28th and made an osteoporosis model mouse to search a cell pro-immunity and relevance with the onset of osteoporosis by immunity restraint agent. As a result, as for the bone absorption of a group of experiments by FK506, decrease of trabecula bone was recognized by a wild type more underneath than enchondral ossification, and, as for positive osteoclast, numbers increased in enchondral ossification for TRAP dyeing more clearly than a group of control again. However, as for the bone absorption in the lower part, as for the osteoporosis by immunity restraint agent, what an immunity system cell such as a T cell was related to was suggested without most than enchondral ossification with a nude mouse by there not being control and a change.I discovered that osteoporosis recovered when we administered Propion acid bacteria fermentatio … More n product (PC) that was a starter of Swiss cheese to this osteoporosis model. We examined a bone absorption restraint effect from this fermentation product this time. I was able to prevent the bone absorption when I administered Propion acid bacteria fermentation product (PC) to an osteoporosis mouse by FK506.In late years a lot of existing DHNA has a naphthoquinone frame the same as vitamins K2 attracting attention in a quantity of bone salt thing having quantity of bone improvement action within a PC.I paid attention to this point, and we accepted bone absorption restraint same as a PC for an osteoporosis model when we administered DHNA alone. As for DHNA, the bone absorption restraint effect of a PC was able to identify a thing by DHNA from what was included in a PC abundantly.I compared osteoclast with control when I added the B cell which was a T cell and the B220 positive that were four twist CD positive in marrow in osteoclast of a mouse namely in vitro of bone bud cell-like strike Rome cell and marrow cell with magnetic beads and increased significantly. Less