Development of stimuli responsive molecular recognition materials for chiral separation

我们开发了一种由刺激响应聚合物和超分子组成的材料系统。这些组合使我们能够通过轻微的温度变化实现手性分离。超分子如手性冠醚（CC）、环糊精（CD）等由于其手性可以识别客体分子，而温敏聚合物则可以通过改变其体积来改变其络合常数。合成了手性冠醚侧链单体和手性环糊精侧链单体，并将其与温敏型NIPAM进行聚合。同时，将CD-NIPAM共聚物链固定在多孔基底孔中，制备了一种新型的手性分离膜。这些聚合物和膜具有主客体识别能力，其识别能力可以通过刺激响应性聚合物的体积变化来控制。这意味着，如预期的那样，通过轻微的温度变化可以发生分子识别型分离。

We developed a material system composing of stimuli responsive polymer and super molecules. Those combination enable us to achieve a chiral separation by slight temperature change. The super molecules, such as chiral crown ether (CC) or cyclodextrine (CD) can recognize guest molecules as its chirality, and thermo responsive polymer can change their complex constant by changing its volume. Chiral crown ether pendent monomer and CD pendent monomer were synthesized for polymerization with thermo responsive NIPAM. Also, the CD-NIPAM copolymer chains were fixed in porous substrate pores, and a novel chiral separation membranes were developed. Those polymer and membranes showed host-guest recognition, and its recognition ability can be controlled by stimuli responsive polymer's volume change. This means that molecular recognition type separation can be occurred by slight temperature change as expected.