With the aim of early convalescence of the occlusal function in the immediate implant after tooth extraction :

本研究的目的是使稀疏的松质骨致密化，以实现拔牙后即刻种植体咬合功能的早期恢复。首先，我们开发了具有足够可塑性的磷酸钙水泥，使其易于成型。该水泥具有良好的处理性能和生物相容性。此外，我们开发了三明治技术，并建议它是有效的颌骨隆胸。制备多孔结构的磷酸钙水泥是可能的，但制备具有生物可吸收性的磷酸钙水泥是不可能的。制备具有生物可吸收性的骨水泥是实现松质骨致密化的必要条件。因此，我们开发了可从14号针注射的β- tcp - cm -几丁质复合材料。将该复合材料植入软组织和骨组织时，未观察到炎症反应。表明该材料具有良好的生物相容性。植入BMP后，皮下组织有活性骨形成。报道了在胶原蛋白上发生疯牛病等问题，而胶原蛋白通常被用作BMP的载体。结果表明，该复合材料适合作为BMP的载体。组织学研究评估了该复合材料作为骨替代物的有效性。种植1周后，材料表面可见活性骨形成。随着时间的推移，可以看到材料的吸收和骨的置换。结果显示松质骨致密化。提示拔牙后即刻种植体的咬合功能有早期恢复的可能。

The purpose of this study was to densify the sparse cancellous bone to achieve the early convalescence of the occlusal function in the immediate implant after tooth extraction. Firstly, we developed the calcium phosphate cement with the sufficient plasticity for easy molding into the desired shape. This cement had the good handling property and biocompatibility. Furthermore, we developed the sandwich technique and suggested that it was effective for the jaw bone augmentation. Although it was possible to make the calcium phosphate cement with porous structure, it was impossible to develop the calcium phosphate cement with bio-absorbability. It is necessary to make the cement with bio-absorbability for densification the cancellous bone. Therefore, we developed β-TCP-CM-chitin composite material that was injectable from the # 14 needle. No inflammatory response was observed when this composite was implanted in soft tissue and bone tissue. It showed this material had good biocompatibility. Active bone formation was observed in subcutaneous tissue when it was implanted with BMP. The problems such as BSE on the collagen are reported, while collagen was used for the carrier for BMP usual. It was suggested that this composite material was suitable for the carrier for BMP. Histological investigation was carried out to evaluate the effectiveness of this composite material as a bone substitute. At I week after implant, active bone formation was observed on the surface of the material. Absorption of the material and replacement to the bone was seen with time. It was showed that the cancellous bone was densified. These results suggested that the possibility of the early convalescence of the occlusal function in the immediate implant after tooth extraction.