The molecular epidemiological analyses of G6PD deficiency in Vietnam

与我们组开展了越南G6PD缺乏症分子流行病学分析的合作研究。在这个项目的3年内，我们可以收集河内新生儿的干血样本(5899份)，并用我们的Formazan方法进行筛查。G6PD缺乏症阳性率为3.1%。在菲律宾人中，这个值几乎是相同的。而来自河内附近的河平省，特别是来自和平省的蒙古族，其基因价值为18%，占32%。从北部(河内，和平)，中部(清化，顺化)和越南南部(胡志明市)，在他们知情同意的情况下，我们可以收集137个样本进行MPTP方法的基因组分析。这些民族包括金族、蒙族、喀土族、道族、拉克莱族和泰族。可以识别出高哈、查塔姆、中国5号、Viangchan、Union、广州和开平等7个不同的变种。联盟在加图的蒙族和文昌族占主要地位。这些变种在印度尼西亚、马来西亚、新加坡、菲律宾和泰国等邻国很受欢迎。但从越南语中，我们很难获得Mahidol、地中海和Vanua Lava的变体。

The cooperative research of molecular epidemiological analyses of G6PD deficiency in Vietnam between Dao's group and our group has been developed. Within 3 years of this project, we could collect the dried blood samples (5,899) from newborn babies in Hanoi and screen them by our Formazan method. The positive incidence of G6PD deficiency was 3.1 %. This value was nearly same in Filipinos. However, its value from Hor Binh Province near Hanoi was 18 % and especially from Muong nations in Hor Binh, 32 %.From northern (Hanoi, Hoa Binh), central (Khanh Hoa, Hue) and southern Vietnam (Ho Chi Minh City) we could collect 137 samples for genomic analyses by MPTP method with their informed consent. Those contained Kinh, Muong, Katu, Dao, Raclei and Tay nations. Seven different variations such as Gaoha, Chatham, Chinese 5, Viangchan, Union, Canton and Kaiping could be identified. Union was major in Muong and Viangchan in Katu. These variants were popular in neighboring countries of Indonesia, Malaysia, Singapore, Philippines and Thailand. But from Vietnamese we could hardly obtain the variants of Mahidol, Mediterranean and Vanua Lava.