Analysis on Pathophysiology of Functional Gastrointestinal Disorders (FGIDs) and Establishment of Comprehensive Evaluation Methods and Treatment of FGIDs

1.标准方法测定固体餐胃和小肠通过时间及各自简易方法的建立：从正常志愿者胃排空(GE)和口盲肠通过时间(OCTT)的测定结果看，用~(13)&GT；C-辛酸(OA)、~(13)&GT；C-乳糖脲(LU)和放射性核素法同时测定GE和OCTT；2.用标准方法测定胃感觉阈值和胃适应性松弛，并建立各自的简易程序：比较标准恒压器法和饮酒试验获得的参数，建议用简易方法(如饮酒试验)评估胃感觉和适应性松弛反应。3.药物对肠易激综合征患者固体餐胃肠道通过时间和直肠感觉阈值的影响：(1)13&gT；C-呼气试验(OA&LU)进行…(2)改善腹泻型IBS患者的症状和生活质量。4.功能性胃肠病患者直肠气囊扩张时脑血流量的测定及应激源(S)对直肠扩张(机械应激源)和/或心算(心理应激源)条件下脑血流量的影响。5.难治性功能性消化不良(FD)心身诊疗策略的建立：半数难治性FD患者被诊断为躯体形式障碍，对常规药物治疗无效。针对这些患者提出了一种新的治疗策略。验证性研究应该是必不可少的。较少

1.Measurement of solid meal gastric and small intestinal transit time by the standard methods and establishment of respective simple procedure :From the results on gastric emptying (GE) and oro-cecal transit time (OCTT) measured by ^<13>C-octanoic acid (OA), ^<13>C-lactose ureide (LU) and radio-isotope method in normal volunteers, it was suggested that simultaneous measurement of GE and OCTT by ^<13>C-breath test be possible and accurate.2.Measurement of gastric perception threshold and gastric adaptive relaxation by the standard methods and establishment of respective simple procedure :Compared parameters obtained from standard barostat method with those by drink test, it was suggested that the simple method (eg, drink test) should estimate gastric perception and adaptive relaxation response.3.Effect of a drug on solid meal gastric and small intestinal transit time and rectal sensory threshold in patients with irritable bowel syndrome (IBS) :(1)^<13>C-breath test (OA & LU) was perform … More ed before and after drug (polycarbophil calcium) administration in IBS patients and normal volunteers, and the drug improved the accelerated GE in IBS.(2)The drug improved the symptoms and quality of life in diarrhea-predominant IBS patients, and in some cases rectal sensory threshold and compliance were also increased.4.Measurement of brain blood flow (BBF) under rectal balloon distension in patients with functional gastrointestinal disorders and the effect of the stressor(s) on BBF (brain-gut interaction)BBF was measured in conditions with rectal distension (mechanical stressor) and/or mental arithmetic (psychological stressor) by positron emission tomography in diarrhea-predominant IBS patients and normal volunteers. Differences in pain response to the stressor(s) and the region of increased BBF between IBS and volunteers are demonstated.5.Establishment of psychosomatic diagnosis and treatment strategy for intractable functional dyspepsia (FD) :Half of intractable FD patients were diagnosed as somatoform disorders who are resistant to ordinary drug therapy. A novel treatment strategy for those patients was proposed. Validation study should be essential. Less