Quantification of cyclical oscillations in cerebral blood volume in human neonates using near-infrared spectroscopy

本研究的目的是通过使用近红外地形图研究健康早产儿和足月儿的氧合血红蛋白和脱氧血红蛋白（[oxyHb]和[deoxyHb]）的振荡，并确定发育中大脑自发振荡的变化。受试者为10名健康足月儿（孕周：37-40周，出生体重：2358- 3400 g），年龄9 - 12天，早产儿11例（孕周：23-34周，出生体重：474-2048g），年龄36-73天（孕后37-46周）。我们使用24通道近红外地形图测量[oxyHb]和[deoxyHb]的变化在24个测量位置，以20 mm的尖点间距测量婴儿安静睡眠时双侧颞叶皮质的血流动力学，所有婴儿均观察到脑血流动力学的自发振荡。为了关注缓慢波动，从24个通道中显示最小基线偏移的通道中选择180秒时间段内的数据（1801个数据点 ...更多信息 在数据中。功率谱分析，然后在这些时期进行。功率谱密度（PSD）分为3个谱窗（0.02- 0.06，0.06 -0.10和0.10-0.15 Hz）。为了比较足月婴儿与早产婴儿的PSD，PSD标准化如下：PSD=（频谱窗面积/PSD总面积）× 100（%）。足月儿左颞区[oxyHb]和[deoxyHb]的周期性波动分别为3.1±0.6（平均值±标准差）和2.9±0.5周期/min，左颞区[oxyHb]和[deoxyHb]的周期性波动分别为3.1±0.6和2.9±0.6周期/min。在右颞区，分别为min。足月早产儿左侧分别为3.9±0.6和4.1±0.7周/min，右侧分别为4.0±0.6和4.1±0.6周/min。在0.02-0.06和0.06-0.10 Hz时，足月儿和早产儿之间的[oxyHb]和[deoxyHb]差异具有统计学显著性。足月儿的频率显著低于早产儿（在0.02-0.06和0.06-0.10 Hz下，足月儿与早产儿：分别为81± 4%和69± 15%（p=0.017），以及16± 4%和28± 14%（p=0.017））。这项研究表明，优势的低频振荡[oxyHb]和[deoxyHb]小于0.10 Hz的颞叶皮层在足月和早产儿的近红外地形。少

The purpose of this study was to investigate the oscillations of oxy- and deoxy-hemoglobin ([oxyHb] and [deoxyHb]) in healthy preterm and term infants by using near-infrared topography and to determine the change in spontaneous oscillation in the developing brain. The subjects were 10 healthy term infants (gestational week : 37-40 weeks, birth weight : 2358-3400g), aged 9 to 12 days, and 11 preterm infants (gestational week : 23-34 weeks, birth weight : 474-2048g), aged 36-73 days (37-46 weeks of postconceptional age).We used 24-channel near-infrared topography to measure changes in [oxyHb] and [deoxyHb] in the bilateral temporal cortices of infants during quiet sleep at 24 measurement positions with interoptode distance of 20 mm. Spontaneous oscillations of cerebral hemodymanics were observed in all of the infants. To focus on the slow fluctuations, data over a period of 180 sec (1801 data points) were selected from the channel among the 24 channels showing the smallest baseline shift … More in data. Power spectral analysis was then performed in these epochs. The power spectral density (PSD) was divided into 3 spectral windows (0.02-0.06,0.06-0.10, and 0.10-0.15 Hz). To compare the PSDs in term infants with those in preterm infants, the PSD was normalized as follows : PSD=(Area of spectral window/Total area of PSD)x100 (%).Cyclical fluctuations of [oxyHb] and [deoxyHb] in term infants were 3.1±0.6 (mean±SD) and 2.9±0.5 cycles/min in the left temporal region and 3.1±0.6 and 2.9±0.6 cycles/min in the right temporal region, respectively. Those at term in preterm infants were 3.9±0.6 and 4.1±0.7 cycles/min on the left side and 4.0±0.6 and 4.1±0.6 cycles/min on the right side, respectively. The difference between term infants and preterm infants was statistically significant at 0.02-0.06 and 0.06-0.10 Hz for [oxyHb] and [deoxyHb]. The term infants had significantly lower frequency than did the preterm infants (Term vs. preterm at 0.02-0.06 and 0.06-0.10 Hz:81±4 % and 69±15 % (p=0.017), and 16±4 % and 28±14 % (p=0.017), respectively). This study demonstrated a predominance of low frequency oscillations in [oxyHb] and [deoxyHb] less than 0.10 Hz in the temporal cortices in both term and preterm infants by near-infrared topography. Less