Application of genetic analysis towards occupational medicine -Development of efficient method for health promotion using genetic data base-

在职业卫生中，生活方式病的管理已成为最重要的问题之一。生活方式疾病的发生是外部因素（包括吸烟、饮酒、饮食和接触）与遗传易感的内部因素相互作用的结果。我们研究了疾病易感性的基因诊断是否有助于支持那些想要改变生活方式的人。结果如下：1）评估干预研究的遗传易感性反馈行为改变; 2）致癌相关基因。1）我们选择了一个工作场所，我们使用了这个干预研究。以420名男性企业员工为研究对象，调查其乙醛脱氢酶2（ALDH 2）2基因型的分布情况。我们将420名参与者随机分为两组。一组为“通知组”，其成员较早地被通知ALDH 2基因型的结果（n=139），另一组为“未通知组 ...更多信息 ”，其成员在稍后的日期被告知ALDH 2基因型的结果（n=203）。在定期体检中发现ALDH 2基因型前后，收集饮酒习惯和实验室数据（GOT、GPT、γGTP）。在携带ALDH 2 ^*1^*1基因型的受试者中，饮酒频率没有显著变化，在告知基因型前后，两组的肝功能实验室数据也没有显著下降。另一方面，对于具有ALDH 2 ^*1^*2基因型的那些人，在告知基因型之前和之后，两组的饮酒频率和肝功能实验室数据没有显著变化。2）采用病例对照研究方法，探讨谷胱甘肽S-转移酶（GST）A1基因多态性、吸烟与口腔癌、尿路上皮癌和前列腺癌的关系。因此，我们发现CYP 1A 1多态性与吸烟者口腔鳞状细胞癌和前列腺癌的风险有关，与非吸烟者尿路上皮癌的风险有关。少

In the occupational health, management of lifestyle diseases has become one of the most important issues. Lifestyle diseases occur as a result of interactions between external factors, including smoking, drinking, diet and exposure, and internal factors that genetic predisposed. We studied to examine whether the genetic diagnosis of susceptibility to disease is useful in supporting those who want to change their life style.Following ire the results: 1) assessment of intervention study that feedback of genetic susceptibility to behavioral change; 2) cancer-causing relevance gene.1) We selected a workplace that used this intervention study. The participants of this study were 420 male employees who wanted to know the re suit of their Aldehyde dehydrogenase (ALDH2) 2 genotype. We divided the 420 participants randomly into two groups. One is the "notified group", the members of which were notified of the result of the ALDH2 genotype earlier (n=139), and the other is the "non-notified group … More ", the members of which were notified of the results of the ALDH2 genotype at a later date (n=203). Drinking habits and laboratory data (GOT, GPT, γGTP) were obtained before and after notification of the ALDH2 genotype from regular medical health check-ups. Among those with genotype ALDH2^*1^*1, there was no significant change in drinking frequencies, nor was there any significant decline in liver function laboratory data in either of the groups before and after notification of the genotype. On the other hand, with regard to those who with genotype ALDH2^*1^*2, no significant changes in drinking frequencies and liver function laboratory data were evident in both groups before and after notification of the genotype. However, the weekly alcohol intake tended to increase in the non-notified group, whereas it tended to decrease in the notified group.2) A case control study was carried out to examine the relationship between the genetic polymorphisms of glutathione S-transferase (GST) Al genes, cigarette smoking and oral, urothelial and prostate cancer. As a result, we found that the CYP1A1 polymorphism was associated with risk of smokers with oral squamous and prostate cancers, and non-smokers with urothelial caner. Less