Development of a novel air pollution monitoring strategy - combining passive sampling with toxicity testing

目前监测空气污染物风险的方法仅限于使用基于化合物的独立毒理学和/或流行病学评估的浓度对特定污染物进行采样分析。这种方法不允许对混合物进行评估，也不允许某一特定化合物可能产生不同的毒性终点，而且是基于较短的采样周期。这项研究旨在开发和评估一种新的方法，结合使用时间集成的被动采样器提取污染物和使用快速体外和体内测试进行毒理学评估。研究结果为污染物影响的敏感评估和根据混合物毒性得出干预指南的基线数据提供了廉价的工具。

Present approaches for monitoring risk of air pollutants are limited to grab sample analysis for specific pollutants using concentrations based on independent toxicological and/or epidemiological assessment of compounds. This approach does not allow for evaluation of mixtures or that a given compound may exert different toxic endpoints and is based on short sampling periods. This research aims to develop and evaluate a novel approach combining extraction of pollutants using time-integrated passive samplers and toxicological evaluation using rapid in-vitro and in-vivo assays. The outcomes provide inexpensive tools for sensitive assessment of pollutant effects and baseline data to derive intervention guidelines based on mixture toxicity.