Microfluidic Active-Feedback THz Biosensor for Direct, Sensitive and Selective Exosome and Virus Detection in Aqueous Environments (“MATISSE”)

这一跨学科项目旨在整合项目合作伙伴的基础生化、生物医学、微流体、超材料传感器和有源电路设计专业知识，为太赫兹生物传感研究开辟一个可能的场所。这一新的方法将带来一个广泛适用的集成太赫兹系统，用于在本地溶液中进行直接、灵敏和选择性的真实生物医学常规测量。该方法将首次能够在病理生理密度水平上动态在线分析水溶液中的囊泡结构，即外切体和病毒，以便深入了解基本的生化相关性和疾病原因。将有源反馈功率放大器和生物化学功能化共振传感组件集成到微流控流动池中，将使水溶液中THz生物分析物的直接检测达到生理相关的检测水平。兴趣优先计划的主要目标反映在拟议项目的雄心壮志中，该项目通过将集成模拟电路设计、基于超材料的物理原理和先进的生物分析等不同的技术学科相互连接起来，从根本上深入到新一代有源微流控传感器，从而在太赫兹研究中打开未知的可能性。

This interdisciplinary project aims to integrate the fundamental biochemical, biomedical, microfluidic, metamaterial-sensorics and active circuit design expertise of the project partners, to open up a venue of possibilities in the field of THz biosensing research. This novel approach will bring about a widely applicable integrated THz system for direct, sensitive and selective real-world biomedical routine measurement in native solutions into tangible proximity. The approach will enable for the first time the dynamic on-line analysis of vesicular structures, i.e. of exosomes and viruses, in aqueous solutions at pathophysiological density levels, in order to gain insights into fundamental biochemical correlations and causes of disease. The integration of an active-feedback power amplifier with a biochemically functionalized resonant sensing component into a microfluidic flow cell will enable the milestone of direct THz bioanalyte detection in aqueous solutions at physiologically relevant detection levels. The main objectives of the INTEREST priority program are reflected in the ambitions of the proposed project to open unexplored possibilities in THz research by interconnecting the diverse technological disciplines of integrated analogue circuit design, metamaterial-based physical principles and advanced bioanalytics to fathom into a fundamentally new generation of active microfluidic sensorics.