Deep observational researches regarding the profound structures, morphogenesis and regeneration of nerves, bloods and muscles existing in the visceral internal organs as well as four limbs, using sui genesis technology of whole-mount staining, and molecul
Deep observational researches regarding the profound structures, morphogenesis and regeneration of nerves, bloods and muscles existing in the visceral internal organs as well as four limbs, using sui genesis technology of whole-mount staining, and molecul
批准号:
16590139
负责人:
TANAKA Shigenori
金额:
$2.24万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2004
资助国家:
日本
项目状态:
已结题
起止时间:
2004 至 2005
中文摘要
交感神经在心脏中分布的形式和结构的阐明,即心脏神经的研究得到了进一步的推进。人们发现,心脏神经从交感神经干的非常广泛的区域中大量出现,相互之间进行着非常多的交流。而且,它们的运行方式或形式比迷走神经的心脏分支复杂得多。因此,这些心脏神经的特征比迷走神经的心脏分支更难阐明。其中,适用于研究的人体例子比其他脊椎动物的例子要多得多,而且,它们相互交流,它们的走行图形比迷走神经的心脏分支复杂得多。为了解决这一难题,我们应用了新的具体技术。使用这项技术,我们能够…用酒精增加脂肪酒精,用茜素红S染色神经,并阐明所有人和其他脊椎动物的实验标本中的血管。结果发现,心脏神经从交感神经干起于从颈部到胸椎最低水平的广泛区域,即人体标本的ThI0(更多是ThI2)。此外,不仅从人体解剖学的角度从根本上阐明了人体身体的三维结构,也是从脊椎动物比较解剖学和胚胎学。我们已经在学术会议(日本临床解剖学研究会第8次会议和日本周围神经研究会第16次会议)上介绍了这些结果。国际科学杂志关于心脏神经及其分支形态的稿件正在修改中。采用比小鼠和大鼠更接近人类形态的全胚胎免疫染色方法对心脏神经的形态和形态发生进行澄清(博士课程学生提交的论文)。这项研究的结果发表在日本解剖学学会第110期上。为国际科学杂志撰写的稿件也在筹备之中。麝鼠肝脏的发生形式,临床医学意义(内科2004:解剖学.环境学.2004年)已得到澄清。此外,还阐明了支配上颌提肌和下颌神经的神经的形态(Clin Anat 2004;Surg Radiol Anat 2004)。目前,我们努力推进研究,以分析镰状韧带和肝圆韧带中走行的动脉、静脉和神经的密切结构和形态发生,并阐明剑突周围淋巴管与人身体和麝鼠的形态和功能关系。这些结构和这些结构的根含义正在从胚胎学和临床的角度得到澄清,并与临床研究人员建立合作关系。我们还与医生合作进行研究,以开辟测量、诊断和治疗异常骨骼的新方法,以及头颈部肌肉发生的分子和组织化学研究。较少
英文摘要
Researches of elucidation of form and structure of the sympathetic nerve distributed in the heart, that is, cardiac nerves were furthermore promoted.The cardiac nerves were found to arise numerous in number from very broad areas of the sympathetic trunk, communicating each other very numerously.Furthermore, their patterns or forms of running were much more complicated than those of the cardiac branches of the vagus nerve.As a result, clarification of features of these cardiac nerves are difficult than the cardiac branches of the vagus nerve.Inter alia, human examples applicable for researches are exceedingly large as those of other vertebrate and further more, they communicate each other and their coursing figures are much more complicated than those of the cardiac branches of the vagus nerve. Therefore, the complete clarification of human cardiac nerves are difficult article.In order to resolve this difficulty, we applied new specific technology. Using this technology, we are able to … More grease alcohol by using alcohol, stain nerves with arizarin red S, and to elucidate blood vessels in all experimental examples of humans and other vertebrates.In consequence, the cardiac nerves were found to arise from the sympathetic trunk in a wide area from the cervical until the lowest thoracic level, i.e., ThI0 (and further more ThI2) in human examples.Furthermore, the three-dimensional structures of human cadavers have been clarified fundamentally not only from the human anatomical point of view, but also comprehensively from the vertebrate comparative anatomy and embryology.We have been made presentations of these results in academic conferences (the 8^<th> Meeting of Japanese Research Society of Clinical Anatomy and the 16^<th> Meeting of Japanese Research Society of Periphera Nerve).Therewithal, the contribution manuscripts of the international science magazine concerning the form of the cardiac nerves and branches are being to retouched and corrected.The clarification of morphology and morphogenesis of the cardiac nerves are performed by using methods for whole embryo immunity staining in muskrats which are nearer human's form than the mouse and the rat for the form formation (doctor's course student's submitting thesis).These results of this research were presented in the 110th in Japanese Anatomy Association. Contribution to the international science magazine is also being prepared. The form of generation of the muskrat liver, clinical medicine meaning (Endoclinology 2004 : Anat.Enbryol. 2004) has been clarified. Furthermore, figures of the nerves innervating the levator palate muscle and mandibular nerve were elucidated (Clin Anat 2004 ; Surg Radiol Anat 2004).At the moment, we make exertions to advancing researches in order to analyze the intimate structures as well as morphogenesis of arteries, veins and nerves coursing in the falciform and teres hepatic ligaments and to clarify the morphological as well as functional relationships-of lymphatic vessel around the xiphoid process with the live in the human cadavers and also in muskrats. These structures and root meanings of these structures are being clarified from the embryological and clinical viewpoints, building up co-operation with clinical researchers. We are also making collaborative researches with doctors in order to open up new method of measurement, diagnosis and treatment of abnormal bones, and also the molecular and histochemical researches of genesis of head and neck muscles. Less
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DOI:
10.1359/jbmr.040126
发表时间:
2004-06-01
期刊:
JOURNAL OF BONE AND MINERAL RESEARCH
影响因子:
6.2
作者:
[Komatsubara, S, Mori, S, Norimatsu, H]
通讯作者:
Norimatsu, H
Surgical anatomy of the innervation of the major duodenal papilla in human and Suncus murinus, from the perspective of preserving innervation
从保留神经支配的角度对人和鼠十二指肠乳头的神经支配进行外科解剖
DOI:
--
发表时间:
2005
期刊:
Pancreas 30・3
影响因子:
--
作者:
[Yi SQ, Ohta T, Miwa K, Shimokawa T, Akita K, Itoh M, Miyamoto K]
通讯作者:
Miyamoto K
Gradual nerve elongation affects nerve cell bodies and neuro-muscular junctions
神经逐渐伸长影响神经细胞体和神经肌肉接头
DOI:
--
发表时间:
2005
期刊:
Hand and Surgery 10・2
影响因子:
--
作者:
[Ikeda K, Matuda M, Yamauchi D, Tomita K, Tanaka S]
通讯作者:
Tanaka S
An anatomical study of the levator veli palatini and superior contrictor with special reference to their nerve supply
提腭帆和上缩肌的解剖学研究,特别是其神经供应
DOI:
--
发表时间:
2004
期刊:
Surg Radiol Anat 26(2)
影响因子:
--
作者:
[Terada N, Kinter M, Kidd G, Bjartmar C, Trapp BD., Shimokawa T]
通讯作者:
Shimokawa T
Cellular localization of endocrine cells in the adult pancreas of the house music shrew, Suncus murinus
家乐鼩鼩成年胰腺内分泌细胞的细胞定位
DOI:
--
发表时间:
2004
期刊:
ene comparative endocrinology 136・2
影响因子:
--
作者:
[Yi SQ, Akita K, Shimokawa T, Nakatani T, Tanaka S et al.]
通讯作者:
Tanaka S et al.
共 13 条
Development for Advanced and Practical Application of Spatial Measurement Technology Using Laser Scanner Equipped UAV
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批准号:18H01563
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.56万
-
财政年份:2018
-
负责人:TANAKA Shigenori
-
依托单位:
Development of theoretical methods for interaction analysis of protein-ligand systems in computational drug design
-
批准号:26460035
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2014
-
负责人:TANAKA Shigenori
-
依托单位:
First-principles simulations of water on the basis of quantum Monte Carlo and fragment molecular orbital methods
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批准号:23540451
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
-
财政年份:2011
-
负责人:TANAKA Shigenori
-
依托单位:
Elucidation of three dimension structure of the cardiac nerves and branches and of liver- distributing arteries in the adults and embryos of human and muskrat beavers, using our unique technology and whole mount in situ hybridication
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批准号:18590164
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.48万
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财政年份:2006
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负责人:TANAKA Shigenori
-
依托单位:
Pursuit and Elucidation of the Morphogenesis of Branchial Nerve, Blood Vessels and Visceral Organs, Applying Whole-mount Immunostaining and Biochisto-as well as Biochemical Staining Methods
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批准号:14570008
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2002
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负责人:TANAKA Shigenori
-
依托单位:
Three-dimensional analysis of the morphogenesis of nerve branches and vessels distributed to the heart and bronchial organs of embryos, using whole-mount immunohistochemical staining and moleculohistoochemical methods.
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批准号:12670010
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:TANAKA Shigenori
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依托单位:
A Three-dimensional Morphological Study on the Development of Nerves, Vessels and Muscles in the Branchial Organs
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批准号:10670010
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1998
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负责人:TANAKA Shigenori
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依托单位:
A THREE-DIMENSIONAL STUDY ON THE DEVELOPMENT OF THE NERVES,VESSELS AND THE MUSCLES IN THE CHICK AND MAMMALIAN EMBRYOS USING A WHOLE MOUNT-IMMUNOHISTOCHEMICAL STAINING
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批准号:07670006
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:TANAKA Shigenori
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依托单位:
Theoretical and Computer-Simulation Studies for Correlational Properties of Dense Hydrogen Plasmas
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批准号:63580002
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1988
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负责人:TANAKA Shigenori
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依托单位:
海外基金