The development of new bioactive cement for treatments of fractures, bone defects, and artificial joints

聚甲基丙烯酸甲酯（PMMA）骨水泥在骨科手术中广泛应用于假体固定；然而，骨与骨水泥之间的界面是一个薄弱的区域。以γ-甲基丙烯氧基丙基三甲氧基硅烷（MPS）和醋酸钙为改性剂，制备了具有生物活性的PMMA水泥。本研究的目的是比较改良骨水泥与传统骨水泥的处理、力学和组织学特性。改良后的标本具有较高的骨与种植体之间的结合强度。改良PMMA骨水泥在植入后3周内推出载荷达到1.60 MPa，并一直维持到植入后8周，而传统骨水泥在本研究期间的推出载荷都很低。组织学观察和微焦x线计算机断层扫描（micro-CT）显示，改性骨水泥具有传统PMMA骨水泥所缺乏的骨传导能力。改良PMMA骨水泥周围钙化骨的百分比大于30%，而常规骨水泥周围钙化骨的百分比小于10%。我们发现这种改良可以有效地为PMMA骨水泥提供骨传导，从而在植入后很长一段时间内提供稳定固定的可能性。

Polymethylmethacrylate (PMMA) bone cement is widely used for prosthetic fixation in orthopaedic surgery ; however, the interface between bone and cement is a weak zone. We developed a bioactive PMMA cement through modification with γ-methacryloxypropyltrimethoxysilane (MPS) and calcium acetate. The purpose of this study was to compare the handling, mechanical and histological properties of the modified bone cement with those of the conventional cement. The modified specimens exhibited higher bonding strength between bone and implant. The push-out load of the modified PMMA bone cement reached 1.60 MPa in 3 weeks, which was maintained up to 8 weeks after implantation, while those of the conventional bone cement remained low throughout the examined periods in this study. Histological observation and micro-focus X-ray computed tomogram (micro-CT) images showed the modified cement exhibited osteoconduction, which the conventional PMMA bone cement lacked. The percentage fraction of the calcified bone around the modified PMMA bone cement was over 30%, whereas that of the conventional cement was less than 10%. The modification was found to be effective in providing PMMA bone cement with osteoconduction, thus providing probability of stable fixation in a long period after implantation.