Effect of Growth factor on intrauterine growth retardation and factor for growth factor production

1.胎盘生长因子（PIGF）是一种来源于胎盘的生长因子，属于VEGF家族。VEGF和PLGF可能在滋养细胞增殖中起作用。sVEGFR1是VEGF和PLGF的可溶性受体。sVEGFR1抑制VEGF和PLGF的功能活性。我们测量了子痫前期血清中游离VEGF、PLGF和sVEGFR1的水平。子痫前期血清游离VEGF、PLGF水平明显低于正常妊娠血清。子痫前期血清中sVEGFR1水平高于正常妊娠血清。为了阐明子痫前期的病理生理机制，我们检测了子痫前期血清对培养的绒毛膜癌细胞株中VEGF、PLGF和sVEGFR1产生的影响。子痫前期血清中游离VEGF水平低于正常妊娠血清。P1GF水平在两组间无明显变化。子痫前期血清中sVEGFR1水平高于正常妊娠血清。在子痫前期，更多a可能增加sVEGFR1的产生，保持游离VEGF或P1GF水平的降低。为了阐明妊高征（PIH）的病理生理机制，我们检测了妊高征患者胎盘中VEGF、PLGF和sVEGFR1 mRNA的表达。妊高征胎盘中PLGF mRNA的表达明显低于正常妊娠（p=0.014）。妊高征胎盘中VEGF和sVEGFR1 mRNA的表达差异较大，与正常妊娠无明显差异。而VEGF与sVEGFR1的表达呈正相关（r=0.81）。我们研究了妊娠期高血压疾病与人肾素基因和/或人凝血因子XI基因的关系。我们发现了他们之间的联系。我们对反复流产和子痫前期患者的抗磷脂酰丝氨酸-凝血酶原抗体进行了检测。为了了解补体的激活情况，我们对抗磷脂抗体（APA）阳性的复发性流产和流产患者补体的变化进行了评价。补体活化在抗磷脂抗体阳性的复发性流产和妊娠丢失中被证实。少

1.Placental Growth Factor(PIGF) is a growth factor originated from placenta belong to VEGF family. VEGF and PLGF may play a role of proliferation of trophoblast. The sVEGFR1 is soluble receptor for VEGF and PLGF. The sVEGFR1 suppresses functional activity of VEGF and PLGF. We measured the levels of free VEGF, PLGF and sVEGFR1 in preeclamptic sera. The levels of free VEGF and PLGF in preeclamptic sera were lower than those in normal pregnant serum. However the levels of sVEGFR1 in preeclamptic sera were higher than that in normal pregnant serum.2.To elucidate the pathophysiology of preeclampsia, we examined the effects of preeclamptic sera on the production of VEGF, PLGF and sVEGFR1 from cultured choriocarcinoma cell line. The levels of free VEGF in preeclamptic sera were lower than those in normal pregnant serum. The levels of P1GF had not significant change between them. However the levels of sVEGFR1 in preeclamptic sera were higher than that in normal pregnant serum. Preeclamptic ser … More a may play a role of increased production of sVEGFR1 keeping decreased levels of free VEGF or P1GF in preeclampsia.3. To elucidate the pathophysiology of pregnancy induced hypertension (PIH), we examined the expression of VEGF, PLGF and sVEGFR1 mRNA in placenta taken from PIH patients. The expression of PLGF mRNA in PIH placenta were significantly lower than those in normal pregnancies (p=0.014). The expression of VEGF and sVEGFR1 mRNA in PIH placenta had wide variation and were not different from those of normal pregnancies. However, the positive correlation was suggested between the expression of VEGF and sVEGFR1 (r=0.81).4. We studied the relationships between hypertensive disorders of pregnancy and the human Renin gene and/or the human coagulation factor XI gene. We detected the association between them.5. We evaluated an anti-phosphatidylserine-prothrombin antibody in patients with recurrent abortion and preeclampsia and detected this antibody in them.6. In order to know the comlement activation, the changes of compliment were evaluated in recurrent abortion and pregnancy loss patients with antiphospholipid antibody(APA) positive. The comlement activation was demonstrated in recurrent abortion and pregnancy loss with antiphospholipid antibody positive. Less