Research of Bioactive Alkaloids with Polycyclic Skeletons

石蒜生物碱和瑞香碱分别是从石松科球藓和瑞香属植物中提取的一大类植物成分。这些结构不同的生物碱通常具有不寻常的骨架，其中许多从生物发生和生物学角度继续具有兴趣，并为全合成提供了具有挑战性的靶标。对石蒜属植物石松和石蒜属植物的提取物进行了研究，分离出新的生物碱，车前素B，石蒜素A和暗色草素类化合物。兰诺替丁类化合物的分离与鉴定阿克利叶表现出较高的NGF生物合成活性。番茄红素和番茄红素A是从灌木和棒叶番茄中分离得到的。ROBGROSTUM)。从哈密尔顿链霉菌中分离得到对乙酰胆碱酯酶有抑制作用的番茄红素A，并对其结构进行了修正。S…其中更多的新生物碱对神经营养因子的生物合成有一定的影响。瑞香生物碱是瑞香科瑞香属植物的一类融合杂环天然产物。这些环系统作为具有挑战性的目标在全合成和生物合成研究中引起了极大的兴趣。在寻找具有独特结构和生物活性的瑞香碱的过程中，从瑞香叶中分离得到两个新的稠合五环生物碱，分别为瑞香素C和D，分别由1-氮杂双环[5.2.2]十一烷、六氢萘-L-酮和环戊烷环组成，并从瑞香叶中分离得到瑞香素A-D。瑞香素C和D可诱导人星形细胞瘤细胞分泌神经营养因子。从东北红豆杉种子中分离得到两个新的紫杉类化合物：紫杉碱M和紫杉醇N。Et Zucc.并根据波谱数据对其结构进行了鉴定。泰索匹定M在较高浓度时降低了解聚过程。较少

The Lycopodium and Daphniphyllum alkaloids represent a large family of plant constituents obtained from the club moss belonging to Lycopodiaceae and trees of the genus Daphniphyllum (Daphniphyllaceae), respectively. These structurally diverse alkaloids often possess unusual skeletons, and many of them continue to be of interest from biogenetic and biological points of view as well as providing challenging targets for total synthesis.Investigation on extracts of Lycopodium complanatum and L. obscurum (Lycopodiaceae) resulted in the isolation of new alkaloids, complanadine B, lycopladine A, and obscurumines. Lannotinidines isolated from L. annotinum and L. annotinum var. acrifolium showed elevated activity of NGF biosynthesis. Lycopodatines and lycovatine A were isolated from L. inundatum and L. clavatum var. Robustum, respectively. Lycoperine A which showed inhibition of acetylcholinesterase and nankakurine B were isolated from L. hamiltonii and structure of nankakurine A was revised. S … More ome of these new alkaloids showed some effects on neurotrophic factor biosynthesis.Daphniphyllum alkaloids are a family of fused-heterocyclic natural products elaborated by trees of the genus Daphniphyllum (Daphniphyllaceae). These ring systems have attracted great interest as challenging targets for total synthesis^3 as well as biosynthetic studies. In our search for structurally unique and biogenetically interesting Daphniphyllum alkaloids, two novel fused-pentacyclic alkaloids, daphmanidins C and D, consisting of an 1-azabicyclo[5.2.2]undecane, a hexahydronaphthalen-l-one, and a cyclopentane rings, and daphtenidines A-D were isolated from the leaves of Daphniphyllum teijismanni. Daphmanidins C and D induced secretion of neurotrophic factors from human astrocytoma cells.Two new taxoids, taxezopidines M and N, have been isolated from seeds of the Japanese yew Taxus cuspidata Sieb. et Zucc. and the structures were elucidated on the basis of spectroscopic data. Taxezopidine M reduced the depolymerization process at higher concentration. Less