Development of Multi Element Compounding Reaction System by Highly Coordinated Transition Metal Complexes

过渡金属催化反应已经成熟，成为碳-碳和碳-硅键形成的强大，选择性和高产的方法，并且这种过程通常用于从材料科学到天然产物合成的广泛领域。过渡金属配合物大致分为中性、阳离子和阴离子配合物。前两者作为有机合成催化剂在学术界和工业界都得到了广泛的应用，而后者在应用上相对落后。由中性配合物与有机金属试剂反应形成的阴离子配合物具有很高的电子密度。因此，认为阴离子配合物的金属中心或π-碳配体的亲核性和给电子能力比相应的中性配合物强。我们通过关注阴离子络合物的这些特征，开发了使用烷基卤化物和/或氯硅烷的碳-碳和碳-硅键形成反应的新方法。

Transition metal-catalyzed reactions have matured into powerful, selective, and high-yielding methods for carbon-carbon and carbon-silicon bond formation, and such processes are routinely used in the wide fields ranging from materials science to natural product synthesis. Transition metal complexes are classified broadly into neutral, cationic, and anionic complexes. The former two have been widely used as catalysts for organic synthesis in both academia and industry while the latter is applicably behind. Anionic complexes formed by the reaction of neutral complexes with organometallic reagents possess high electron densities. Consequently, it is considered that the nucleophilicity at the metal center or π-carbon ligands, and the electron-donating ability of anionic complexes would be enhanced in comparison with the corresponding neutral complexes. We have developed new methodologies for carbon-carbon and carbon-silicon bond forming reactions using alkyl halides and/or chlorosilanes by drawing focus to these characteristics of an anionic complex.